Results 131 to 140 of about 39,640 (202)

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Carta de 1961-02-02 a José Ferrater Mora des de Chicago (Estats Units d'Amèrica)

, 1961
Nef demana l'opinió de Ferrater sobre el seu ...
Nef, John
core  

Targeting metabolism and membrane: Neferine synergizes with gentamicin against <i>Escherichia coli</i> by disrupting FNR/ArcA-mediated homeostasis. [PDF]

Virulence
Yan Y, Zhao M, Zhao H, Yan X, Kong L, Ma H.   +5 more
europepmc   +1 more source

The Nef protein of primate lentiviruses

The Nef protein of primate lentiviruses acts as an important virulence factor in vivo both in monkeys and in humans. Among a human cohort of long-term non-progressors, several Nef defective HIV1 viruses have been isolated, indicating that Nef may ...
Trono, Didier, Piguet, V
core   +1 more source

Neferine-Targeted Inhibition of TrxR1 Triggers Apoptosis Through Disrupting Redox Homeostasis in Pancreatic Cancer Cells. [PDF]

Mol Carcinog
Yuan X, Jiang S, Zhang G, Wang Y, Xie Q, Li D, Lu T, Liu H, Li X, Zhang J, Xu M, Zhou L.   +11 more
europepmc   +1 more source

Virus-induced vesicular acidification enhances HIV immune evasion. [PDF]

iScience
Yaple-Maresh ME, Flores-McGregor GG, Zimmerman GE, Chen C, Collins KL.   +4 more
europepmc   +1 more source

HIV-1 Nef inhibits the JAK/STAT signaling pathway by inducing proteasomal degradation of STAT1. [PDF]

PLoS One
Rodrigues RL, da Silva-Januário ME, Apolloni VB, Espada CE, Jorge TR, Tavares LA, de Carvalho AN, Souza JP, Arruda E, Assunção-Miranda I, Mansur DS, daSilva LLP.   +11 more
europepmc   +1 more source

Nef' and Durr concepts in the Qur'an

, 2016
Araştırmada, Kur'an'ın iki temel kavramı olan "nef'" ve "durr" kavramları çalışılmıştır. Araştırma, giriş, üç bölüm ve sonuçtan oluşmaktadır. Giriş bölümünde, araştırmanın konusu, önemi, amacı, yöntemi ve kaynakları kısaca anlatılmıştır.
Sharifeen, Mohtaseb Rakad
core  

Nef and Vpu protect infected cells from ADCP mediated by plasma from people with HIV-1. [PDF]

mBio
Bélanger É, Tauzin A, Tajebe F, Chandravanshi M, Yang D, Chen H-C, Chiu T-J, Bourassa C, Medjahed H, Tolbert WD, Durand M, Richard J, Huryn DM, Stäger S, Pazgier M, Finzi A.   +15 more
europepmc   +1 more source

HIV-1 Nef generates lasting innate immune memory in haematopoietic stem and progenitor cells in vivo. [PDF]

EMBO Rep
Fleetwood AJ, Mukhamedova N, Dragoljevic D, Lee MKS, Xu Y, Dona MSI, Hsu I, Bertuzzo Veiga C, Takeuchi F, Crossett B, Tran D, Pinto AR, Bukrinsky M, Murphy AJ, Sviridov D.   +14 more
europepmc   +1 more source