Results 111 to 120 of about 39,640 (202)
PLoS ONE, 2007 The Nef protein acts as critical factor during HIV pathogenesis by increasing HIV replication in vivo via the modulation of host cell vesicle transport and signal transduction processes.
Claudia Haller +2 more
doaj +1 more source
Biology of HIV-Nef in vivo [PDF]
, 2007 HIV-Nef is established as an important factor for pathogenicity during HIV infection. The exact role and underlying mechanisms however are still unclear.
Koenen, P.G.F.
core +14 more sources
, 2004 Human immunodeficiency virus type 1 (HIV-1) Nef interacts with the clathrin-associated AP-1 and AP-3 adaptor complexes, stabilizing their association with endosomal membranes. These findings led us to hypothesize a general impact of this viral protein on
Douglas Hitchin +19 more
core +1 more source
Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation
Advanced Science, Volume 13, Issue 53, 24 September 2026.Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan +11 more
wiley +1 more source
Genetic determinants of HIV-1 subtype C Nef-mediated SERINC3 down-regulation
Virology JournalBackground Nef-mediated down-regulation of the host restriction factors SERINC3 and SERINC5 significantly enhances HIV-1 infectivity. Natural Nef polymorphisms that affect SERINC3 down-regulation are not as well-characterised as those that affect SERINC5
Nikeisha Samlall +6 more
doaj +1 more source
, 2007 We present a didactical system for learning and exploring Nef polyhedra and the implementation of an AutoCAD entity representing a Nef polyhedron.
Jeremy Tammik
core
Identification of Nef region interacting with ASK1.
, 2013 (A) Using Nef core domain (57-207 aa) sequences, two distinct Nef truncations were designed for mammalian two hybrid studies by successively deleting 33 aa form C-terminal and subsequent cloning in pACT vector so as to obtain Nef (57-174 aa), Nef (57-141
Smrati Bhadauria (422141) +7 more
core +1 more source
Annals of Neurology, Volume 100, Issue 3, Page 628-640, September 2026.Objective Dysarthria is one of the most common and disabling side effects of subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's disease (PD). Stimulation often exacerbates speech dysfunction beyond the effects of PD progression, likely because of current spread to structures surrounding the STN.
Petr Krýže +17 more
wiley +1 more source
Nef-mediated CTLA-4 down-regulation.
, 2013 Transient co-expression of CTLA-4 and Nef in 293T cells. a) Left panels: Surface expression of CTLA-4 analyzed by FACS following staining of 293T cells co-transfected with CTLA-4 and either Nefneg or Nefwt vectors.
Rabih Halwani (287270) +14 more
core +1 more source
International Journal of Circuit Theory and Applications, Volume 54, Issue 9, Page 4469-4481, September 2026.A ramp‐based phase‐locked loop (RPLL) active rectifier operating at 40.68 MHz compensates switching delay variations to improve phase alignment. The proposed architecture achieves 90.3% peak power conversion efficiency and 98.0% voltage conversion ratio for high‐frequency wireless power transfer in implantable medical devices.
Woorim Lee +5 more
wiley +1 more source