The Antiviral Factor SERINC5 Impairs the Expression of Non-Self-DNA [PDF]
Viruses, 2023 SERINC5 is a restriction factor that becomes incorporated into nascent retroviral particles, impairing their ability to infect target cells. In turn, retroviruses have evolved countermeasures against SERINC5.
Ruth Serra-Moreno +2 more
exaly +5 more sources
Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity
Viruses, 2021 Host plasma membrane protein SERINC5 is incorporated into budding retrovirus particles where it blocks subsequent entry into susceptible target cells.
Jeremy Luban +2 more
exaly +5 more sources
Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5 [PDF]
MedCommSerine incorporator 5 (SERINC5) restricts the infectivity of various enveloped viruses, including HIV‐1 and severe acute respiratory syndrome coronavirus 2.
Qinya Xie +9 more
doaj +3 more sources
SERINC5 counters retroviruses and non-retroviruses [PDF]
Frontiers in Cellular and Infection MicrobiologySERINC5 (serine incorporator 5), a member of the serine incorporator family, has been identified as a retrovirus restriction factor that inhibits the fusion of virions with the plasma membrane, thus blocking the release of the viral core into target ...
Jinghua Yu
exaly +4 more sources
Virulence, 2022 The host restriction factor serine incorporator 5 (SERINC5) plays a key role in inhibiting viral activity and has been shown to inhibit classical swine fever virus (CSFV) infection. However, the action of SERINC5 in the interaction between host cells and
Mingqiu Zhao +2 more
exaly +4 more sources
SERINC5 Mediates a Postintegration Block to HIV-1 Gene Expression in Macrophages [PDF]
mBio, 2023 HIV-1 antagonizes SERINC5 by redundant mechanisms, primarily through Nef and additionally via envelope glycoprotein. Paradoxically, HIV-1 preserves Nef function to ensure the exclusion of SERINC5 from virion incorporation regardless of the availability ...
Pavitra Ramdas, Ajit Chande
doaj +3 more sources
SARS-CoV-2-encoded small RNAs are able to repress the host expression of SERINC5 to facilitate viral replication [PDF]
Frontiers in Microbiology, 2023 Serine incorporator protein 5 (SERINC5) is a key innate immunity factor that operates in the cell to restrict the infectivity of certain viruses. Different viruses have developed strategies to antagonize SERINC5 function but, how SERINC5 is controlled ...
Salvador Meseguer +13 more
doaj +4 more sources
A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation [PDF]
Viruses, 2023 The host transmembrane protein SERINC5 is incorporated into retrovirus particles and inhibits HIV-1 infectivity. The lentiviral Nef protein counteracts SERINC5 by downregulating it from the cell surface and preventing its incorporation into virions.
Massimo Pizzato +2 more
exaly +4 more sources
SERINC5 co-expressed with HIV-1 Env or present in a target membrane destabilizes small fusion pores leading to their collapse [PDF]
mBioSerine incorporator protein 5 (SERINC5) is a multipass membrane protein that reduces infectivity of retroviruses and other enveloped viruses through incorporating into budding virions and inhibiting their ability to fuse with target cells.
Ruben M. Markosyan +2 more
doaj +2 more sources
RETREG1/FAM134B-mediated micro-ER-phagy in the retrovirus–SERINC5 arms race [PDF]
Autophagy ReportsReticulophagy regulator 1 (RETREG1)/Family with sequence similarity 134 member B (FAM134B) is a selective endoplasmic reticulum (ER)-phagy receptor that mediates starvation-induced macro-ER-phagy, but whether it participates in other pathways mediating ...
Jim Maurice Camilleri +4 more
doaj +2 more sources