Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry [PDF]
Nature Communications, 2023 The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (ICL4). Here, we
Mark Yeager +2 more
exaly +7 more sources
Beyond Impairment of Virion Infectivity: New Activities of the Anti-HIV Host Cell Factor SERINC5 [PDF]
VirusesMembers of the serine incorporator (SERINC) protein family exert broad antiviral activity, and many viruses encode SERINC antagonists to circumvent these restrictions.
Oliver T Fackler
exaly +5 more sources
SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV [PDF]
Journal of Immunology Research, 2017 The serine incorporator 5 (SERINC5) is a recently discovered restriction factor that inhibits viral infectivity by preventing fusion. Retroviruses have developed strategies to counteract the action of SERINC5, such as the expression of proteins like ...
Gracia Viviana Gonzalez Enriquez +2 more
exaly +4 more sources
Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5 [PDF]
MedCommSerine incorporator 5 (SERINC5) restricts the infectivity of various enveloped viruses, including HIV‐1 and severe acute respiratory syndrome coronavirus 2.
Qinya Xie +9 more
doaj +3 more sources
The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection [PDF]
Frontiers in Cell and Developmental Biology, 2022 Serine incorporator (SERINC) proteins 1–5 (SERINC1-5) are involved in the progression of several diseases. SERINC2-4 are carrier proteins that incorporate the polar amino acid serine into membranes to facilitate the synthesis of phosphatidylserine and ...
Janak L Pathak, Shaofen Xu, Qiuyu Wu
exaly +4 more sources
Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5. [PDF]
PLoS Pathogens, 2020 HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our understanding of how naturally occurring global Nef sequence diversity impacts these activities is limited.
Steven W Jin +11 more
doaj +4 more sources
Fungal Ice2p is in the same superfamily as SERINCs , restriction factors for HIV and other viruses [PDF]
Proteins: Structure, Function and Bioinformatics, 2021 Abstract Ice2p is an integral endoplasmic reticulum (ER) membrane protein in budding yeast S. cerevisiae named ICE because it is required for Inheritance of Cortical ER. Ice2p has also been reported to be involved in an ER metabolic branch‐point that regulates the flux of lipid either to be stored in lipid droplets or to be used as membrane components.
Ganiyu O Alli-Balogun, Timothy Levine
exaly +4 more sources
From Beginning to End: Expanding the SERINC3 Interactome Through an Analysis [PDF]
Bioinformatics and Biology Insights, 2022 The serine incorporator (SERINC) family of proteins are a family of multipass transmembrane proteins associated with biosynthesis of serine-containing phospholipids and sphingolipids.
Mckenzie Tu, Sarah Saputo
doaj +2 more sources
Combined effects of restriction factors and transduction adjuvants on lentiviral vector gene transfer efficacy [PDF]
Scientific ReportsRestriction factors include various cellular proteins that detect and impede viral infections. Among them, interferon-induced transmembrane (IFITM) and serine incorporator (SERINC) proteins interfere with the infectious cycle of HIV-1. Consequently, such
Marie Dewannieux +4 more
doaj +2 more sources
HIV-1 Nef Uses a Conserved Pocket to Recruit the N-Terminal Cytoplasmic Tail of Serinc3 [PDF]
VirusesHuman transmembrane proteins Serinc3 and Serinc5 are antiviral restriction factors that inhibit HIV-1 infectivity. In the absence of viral antagonism, Serinc3 and Serinc5 incorporate into the envelopes of nascent virions and inhibit the fusion of virions
Mohammad Karimian Shamsabadi +5 more
doaj +2 more sources