An N-Glycosylated Form of SERINC5 Is Specifically Incorporated into HIV-1 Virions [PDF]
, 2018 SERINC5 is an inhibitor of retroviral infectivity that is counteracted by viral proteins, including HIV-1 Nef. Inhibition of infectivity by SERINC5 is associated with its incorporation into virions. Nef counteracts this inhibition, presumably by removing
Mary K. Lewinski +5 more
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Y86 is critical for SERINC3/5 antagonism by SIVcol Nef.
, 2018 (A) Alignment of the amino acid sequences of HIV and SIV Nef proteins. Dots indicate gaps. Functional amino acid motifs are highlighted. Y residues in SIVcol Nef that were mutated for functional analyses are indicated in green.
Christina M. Stürzel (3752773) +16 more
core +1 more source
Investigating transmitted/founder HIV-1 nef and env effects on SERINC5 inhibition of infectivity [PDF]
, 2017 HIV has killed millions of people since its discovery in the 1980s and continues to be a costly disease that affects millions worldwide. The advent of antiretroviral drug-therapy made this once deadly disease manageable through a daily regimen of drugs ...
Chau, Jasmine
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Orthogonal Enzyme-Substrate Design Strategy for Discovery of Human Protein Palmitoyltransferase Substrates. [PDF]
J Am Chem Soc, 2023 Puthenveetil R +10 more
europepmc +1 more source
Are bats evolving more potent antiviral immune systems? Investigating the evolution and antiviral capacity of SERINC3 in Rhinolophus bats [PDF]
Bats are an incredibly diverse and abundant viral reservoir species. Their immune systems are uniquely anti-inflammatory and anti-viral, often tolerating viral infection without any signs of disease. Several pandemic and emerging viruses have been traced
Loizidou, Erin
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SERINC5: Its Sensitivity to Nef and Restriction of HIV-1
, 2018 The accessory protein Nef of human immunodeficiency virus type 1 (HIV-1) has long been known to enhance the infectivity of HIV-1 progeny virions. The multipass transmembrane proteins serine incorporator 3 (SERINC3) and SERINC5 were recently identified as
Dai, Weiwei
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Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction
, 2017 Among the five serine incorporator (SERINC) family members, SERINC5 (Ser5) was reported to strongly inhibit HIV-1 replication, which is counteracted by Nef.
Jie Yang +10 more
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SERINC5: One antiviral factor to bind them all. [PDF]
PLoS Pathog, 2023 Timilsina U, Stavrou S.
europepmc +1 more source
Rabbits as a model to study HIV-1 infection and the search for new innate immunity players in resting CD4 T cells [PDF]
, 2018 Once infected with human immunodeficiency virus (HIV), currently available pharmacotherapies can only partly control, but not cure infection. Thus, there remains an urgent need for more potent and conceptually novel antiviral therapeutics, including the ...
Baldauf, Hanna-Mari
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