Results 31 to 40 of about 370 (99)
Serinc2 Drives the Progression of Cervical Cancer Through Regulating Myc Pathway
Cancer Medicine, Volume 13, Issue 19, October 2024.ABSTRACT Background As one of the most common malignancies, cervical cancer (CC) seriously affects women's health. This study aimed to investigate the biological function of Serinc2 in CC. Methods Serinc2 expression was surveyed utilizing immunohistochemistry, western blot, and qRT‐PCR.
Xiaoping Wang, Chen Jiang, Qing Li
wiley +1 more source
Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain
Journal of Medical Virology, Volume 96, Issue 2, February 2024.Abstract Membrane‐associated RING‐CH (MARCH) family proteins were recently reported to inhibit viral replication through multiple modes. Previous work showed that human MARCH8 blocked Ebola virus (EBOV) glycoprotein (GP) maturation. Our study here demonstrates that human MARCH1 and MARCH2 share a similar pattern to MARCH8 in restricting EBOV GP ...
Changqing Yu +10 more
wiley +1 more source
SERINC5 inhibits early steps of IAV infection.
, 2022 A-B: HEK293T cells were transiently transfected with SERINC5 DNA, then infected with A/WSN/33 (MOI = 0.05). Supernatants were harvested 24 h.p.i. Virus titers in the culture supernatants were determined by plaque assays.
Zhangling Fan (12095869) +14 more
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Effect of SIVcol Nef on antiviral activity of vertebrate SERINC5 proteins.
, 2018 Infectious virus yield from HEK293T cells co-transfected with proviral HIV-1 NL4-3 IRES eGFP constructs encoding the indicated nef alleles and pBJ5 SERINC expression or control plasmid.
Christina M. Stürzel (3752773) +16 more
core +1 more source
, 2023 Differential expressions of members of Interferon-inducible (A), TRIM (B), Chemokine receptors (CCR) and SERINC (C) family genes by RNA-Seq analyses on CD4 T cells enriched from day 6 in vitro HIV-1BAL infected PBMC from 3 donors.
Julianna Buchwald (14608810) +9 more
core +1 more source
Discovery and characterization of novel Nef-like infectivity factor [PDF]
, 2016 The SERINC family is a highly conserved group of genes which in the human genome comprises 5 members, encoding five homologous multipass transmembrane proteins.
Cuccurullo, Emilia Cristiana
core
, 2023 Equine Infectious Anemia (EIA) is a viral disease that affects all members of the Equidae family. Despite this, donkeys, when infected, are able to suppress clinical signs and keep the viral titer below the threshold of causing disease throughout the ...
Bruna Lopes Bueno
core
A Conserved Acidic-Cluster Motif in SERINC5 Confers Partial Resistance to Antagonism by HIV-1 Nef [PDF]
, 2020 The cellular protein SERINC5 inhibits the infectivity of diverse retroviruses, and its activity is counteracted by the glycosylated Gag (glycoGag) protein of murine leukemia virus (MLV), the S2 protein of equine infectious anemia virus (EIAV), and the ...
Guatelli, John +8 more
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SIVcol Nef relocalizes SERINC5 to the proteasome by an Y86 dependent mechanism.
, 2018 (A) Representative Laser scanning confocal microscopy images of JTAg SERINC3/5 knock-out cells transfected with SERINC5–GFP (S5-GFP; green) alone or together with the indicated AU1-tagged Nef proteins (red). Endogenous lysosomes were stained with an anti-
Christina M. Stürzel (3752773) +16 more
core +1 more source
An investigation of the function of adaptor protein complex 4 (AP-4) [PDF]
, 2019 Vesicle trafficking provides the solution to the ‘sorting problem’ – how the eukaryotic cell maintains the distinct identities, and thus functional properties, of its membrane-bound organelles.
core +2 more sources