Genetic determinants of HIV-1 subtype C Nef-mediated SERINC3 down-regulation [PDF]
Virology JournalBackground Nef-mediated down-regulation of the host restriction factors SERINC3 and SERINC5 significantly enhances HIV-1 infectivity. Natural Nef polymorphisms that affect SERINC3 down-regulation are not as well-characterised as those that affect SERINC5
Nikeisha Samlall +6 more
doaj +2 more sources
Mechanisms of Immune Evasion in HIV-1: The Role of Virus-Host Protein Interactions [PDF]
Current Issues in Molecular BiologyThis review explores the mechanisms by which Human Immunodeficiency Virus type 1 (HIV-1) regulatory proteins manipulate host cellular pathways to promote viral replication and immune evasion.
Antonios Mouzakis +5 more
doaj +2 more sources
Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5
MBio, 2019 It has recently emerged that HIV-1 Nef counteracts the antiviral host proteins SERINC3 and SERINC5. In particular, SERINC5 inhibits the infectivity of progeny virions when incorporated.
Balaji Olety +2 more
exaly +3 more sources
HIV-1 cell-to-cell infection of macrophages escapes type I interferon and host restriction factors, and is resistant to antiretroviral drugs. [PDF]
PLoS PathogensHIV-1-infected macrophages participate in viral transmission, dissemination, and establishment of tissue virus reservoirs. Despite counteracting viral proteins (Vif, Vpu, Vpr and Nef), cell-free virus macrophage infection is restricted by host cell ...
Marie Woottum +9 more
doaj +2 more sources
HIV-1 and BLV are insensitive to SERINC5 restriction under the cell-cell infection [PDF]
Microbiology SpectrumSerine incorporator 5 (SERINC5, SER5) suppresses viral cell-free infection. However, its antiviral potency under viral cell-cell infection is not examined yet.
Changqing Yu +12 more
doaj +2 more sources
SERINC5: One antiviral factor to bind them all [PDF]
PLoS Pathogens, 2023 Uddhav Timilsina, Spyridon Stavrou
doaj +3 more sources
SERINC5 restricts influenza virus infectivity.
PLoS Pathogens, 2022 SERINC5 is a multi-span transmembrane protein that is incorporated into HIV-1 particles in producing cells and inhibits HIV-1 entry. Multiple retroviruses like HIV-1, equine infectious anemia virus and murine leukemia virus are subject to SERINC5 ...
Fei Zhao +14 more
doaj +1 more source
Cell Reports, 2021 Summary: HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5) by redirecting this potent restriction factor to the endosomes and lysosomes for degradation. However, the precise mechanism remains unclear.
Qingqing Chai +13 more
doaj +1 more source
Antiviral Role of Serine Incorporator 5 (SERINC5) Proteins in Classical Swine Fever Virus Infection
Frontiers in Microbiology, 2020 Serine incorporator 5 (SERINC5), a multipass transmembrane protein, protects cells from viral infections. The mechanism by which SERINC5 protects against classical swine fever virus (CSFV) infection is unknown. In this study, overexpression of SERINC5 in
Wenhui Li +24 more
doaj +1 more source
Nef enhances HIV-1 replication and infectivity independently of SERINC5 in CEM T cells [PDF]
, 2023 A primary function of HIV-1 Nef is the enhancement of viral infectivity and replication. Whether counteraction of the antiretroviral proteins SERINC3 and SERINC5 is the cause of this positive influence on viral growth-rate and infectivity remains unclear.
Guatelli, John +7 more
core +1 more source