HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity [PDF]
Retrovirology, 2023 Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 pathogenesis is not well-defined.
Delon Naicker +9 more
doaj +5 more sources
MAbs, 2020 SERINC5 is a multi-pass transmembrane protein that is thought to play a role in serine incorporation during cellular membrane biosynthesis. This protein has also been identified as a human immunodeficiency virus Type 1 (HIV-1) restriction factor.
Sebastian Molnár +2 more
exaly +4 more sources
Serinc5 Regulates Sequential Chondrocyte Differentiation by Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes. [PDF]
J Cell PhysiolABSTRACT The growth plate is the primary site of longitudinal bone growth with chondrocytes playing a pivotal role in endochondral bone development. Chondrocytes undergo a series of differentiation steps, resulting in the formation of a unique hierarchical columnar structure comprising round, proliferating, pre‐hypertrophic, and hypertrophic ...
Hata K +10 more
europepmc +4 more sources
Viruses, 2022 SERINC5 incorporates into HIV-1 particles and inhibits the ability of Env glycoprotein to mediate virus-cell fusion. SERINC5-resistance maps to Env, with primary isolates generally showing greater resistance than laboratory-adapted strains.
Junghwa Kirschman +6 more
doaj +2 more sources
Serinc5 Restricts HIV Membrane Fusion by Altering Lipid Order and Heterogeneity in the Viral Membrane [PDF]
ACS Infectious Diseases, 2023 The host restriction factor, Serinc5, incorporates into budding HIV particles and inhibits their infection by an incompletely understood mechanism. We have previously reported that Serinc5 but not its paralogue, Serinc2, blocks HIV cell entry by membrane
Amanda Ward +2 more
exaly +4 more sources
Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity
Cell Reports, 2019 Summary: HIV-1 Nef enhances virion infectivity by counteracting host restriction factor SERINC5; however, the impact of natural Nef polymorphisms on this function is largely unknown.
Steven W. Jin +10 more
doaj +2 more sources
Murine leukemia virus glycoGag antagonizes SERINC5 via ER-phagy receptor RETREG1. [PDF]
PLoS PathogensSerine incorporator 5 (SERINC5) is a host restriction factor that inhibits the infectivity of certain enveloped viruses, including human immunodeficiency virus type 1 (HIV-1) and murine leukemia virus (MLV), by incorporating into the viral envelope and ...
Iqbal Ahmad +10 more
doaj +2 more sources
Early brain-penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1-related Aicardi-Goutières syndrome. [PDF]
Clin Transl ImmunologyAbstract Objectives Aicardi‐Goutières syndrome (AGS) is a genetic interferonopathy resulting from defects in nucleic acid metabolism and subsequent enhanced type I interferon signalling. We report how an expedited genomic diagnosis in conjunction with natural history data can enable a long‐term brain‐penetrant anti‐inflammatory regimen to optimise ...
Dale RC +13 more
europepmc +2 more sources
HIV-1 Nef Uses a Conserved Pocket to Recruit the N-Terminal Cytoplasmic Tail of Serinc3 [PDF]
VirusesHuman transmembrane proteins Serinc3 and Serinc5 are antiviral restriction factors that inhibit HIV-1 infectivity. In the absence of viral antagonism, Serinc3 and Serinc5 incorporate into the envelopes of nascent virions and inhibit the fusion of virions
Mohammad Karimian Shamsabadi +5 more
doaj +2 more sources
A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef
Cell Reports, 2018 We recently identified the multipass transmembrane protein SERINC5 as an antiviral protein that can potently inhibit HIV-1 infectivity and is counteracted by HIV-1 Nef.
Weiwei Dai +3 more
doaj +2 more sources