Results 41 to 50 of about 930 (139)
mBio, 2023 Human immunodeficiency virus type 1 (HIV-1) Nef hijacks the clathrin adaptor complex 2 (AP-2) to downregulate the viral receptor CD4 and the antiviral multipass transmembrane proteins SERINC3 and SERINC5, which inhibit the infectivity of progeny virions ...
Balaji Olety +4 more
doaj +1 more source
SERINC5 inhibits IAV infection when expressed in virus target cells.
, 2022 A-B: Pseudoviruses ΔEnv/NefG2A-GFP HIV-1NL4-3 bearing IAV HA/NA proteins were used to infect A549 SERINC5-overexpressing cells (20ng p24 antigen) or SERINC5-knockout cells (10ng p24 antigen).
Zhangling Fan (12095869) +14 more
core +1 more source
SERINC5 Potently Restricts Retrovirus Infection
mBio, 2020 The serine incorporator (SERINC) proteins are multipass transmembrane proteins that affect sphingolipid and phosphatidylserine synthesis. Human SERINC5 and SERINC3 were recently shown to possess antiretroviral activity for a number of retroviruses ...
Uddhav Timilsina +4 more
doaj +1 more source
SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5
Nature Communications, 2022 SERINC5, is a cellular multipass transmembrane protein involved in sphingolipid and phosphatydilserine biogenesis and a known retroviral restriction factor. Here, Timilsina et al.
Uddhav Timilsina +4 more
doaj +1 more source
SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue. [PDF]
PLoS Pathogens, 2018 SERINC5 is a host restriction factor that impairs infectivity of HIV-1 and other primate lentiviruses and is counteracted by the viral accessory protein Nef.
Dorota Kmiec +16 more
doaj +1 more source
Influence of different glycoproteins and of the virion core on SERINC5 antiviral activity [preprint] [PDF]
, 2020 Host plasma membrane protein SERINC5 is incorporated into budding retrovirus particles where it blocks subsequent entry into susceptible target cells. Three accessory proteins encoded by diverse retroviruses, HIV-1 Nef, EIAV S2, and MLV Glycogag, each ...
Luban, Jeremy +5 more
core +1 more source
SERINC5 inhibits the fusion of IAV with cellular membrane.
, 2022 A-B: Levels of IAV NP vRNA in infected A549 SERINC5-overexpressing cells (A) or SERINC5-knockout cells (B). C: A549 cells with SERINC5 overexpression were incubated with IAV WSN (MOI = 50) for 60 min, or 90 min, then fixed and stained for nuclei (blue ...
Zhangling Fan (12095869) +14 more
core +1 more source
SERINC Proteins Potentiate Antiviral Type I IFN Induction and Proinflammatory Signaling Pathways
Proceedings, 2020 T cell SERINC proteins were recently identified as human immunodeficiency virus (HIV) restriction factors that diminish viral infectivity by incorporation into virions.
Cong Zeng +8 more
doaj +1 more source
Nature Communications, 2022 SERINC5 is a host-restriction factor preventing HIV progeny entry, which is counteracted by interactions with HIV Nef. Here, Li et al. show that E3 ubiquitin ligase Cullin 3 polyubiquitinates SERINC5 at Lys 130 via K48- and K33-linked ubiquitin chains ...
Sunan Li +6 more
doaj +1 more source
The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection
Frontiers in Cell and Developmental Biology, 2022 Serine incorporator (SERINC) proteins 1–5 (SERINC1-5) are involved in the progression of several diseases. SERINC2-4 are carrier proteins that incorporate the polar amino acid serine into membranes to facilitate the synthesis of phosphatidylserine and ...
Shaofen Xu +12 more
doaj +1 more source