HIV-1 Nef Uses a Conserved Pocket to Recruit the N-Terminal Cytoplasmic Tail of Serinc3 [PDF]
VirusesHuman transmembrane proteins Serinc3 and Serinc5 are antiviral restriction factors that inhibit HIV-1 infectivity. In the absence of viral antagonism, Serinc3 and Serinc5 incorporate into the envelopes of nascent virions and inhibit the fusion of virions
Xiaofei Jia +2 more
exaly +5 more sources
Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction [PDF]
Viruses, 2021 Nef is a multifunctional viral protein that has the ability to downregulate cell surface molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as recently shown, also members of the serine incorporator family (SERINC).
Neeltje A Kootstra, Zita Kruize
exaly +5 more sources
Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5 [PDF]
PLoS Pathogens, 2020 HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our understanding of how naturally occurring global Nef sequence diversity impacts these activities is limited.
Mark Brockman +2 more
exaly +6 more sources
AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4 [PDF]
mBio, 2023 Human immunodeficiency virus type 1 (HIV-1) Nef hijacks the clathrin adaptor complex 2 (AP-2) to downregulate the viral receptor CD4 and the antiviral multipass transmembrane proteins SERINC3 and SERINC5, which inhibit the infectivity of progeny virions ...
Balaji Olety +4 more
doaj +5 more sources
Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5 [PDF]
MedCommSerine incorporator 5 (SERINC5) restricts the infectivity of various enveloped viruses, including HIV‐1 and severe acute respiratory syndrome coronavirus 2.
Qinya Xie +9 more
doaj +3 more sources
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry [PDF]
Nature Communications, 2023 The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (ICL4). Here, we
Susan A. Leonhardt +17 more
doaj +3 more sources
Genetic determinants of HIV-1 subtype C Nef-mediated SERINC3 down-regulation [PDF]
Virology JournalBackground Nef-mediated down-regulation of the host restriction factors SERINC3 and SERINC5 significantly enhances HIV-1 infectivity. Natural Nef polymorphisms that affect SERINC3 down-regulation are not as well-characterised as those that affect SERINC5
Mark Brockman +2 more
exaly +3 more sources
Current drugs for HIV-1: from challenges to potential in HIV/AIDS [PDF]
Frontiers in Pharmacology, 2023 The human immunodeficiency virus (HIV) persists in latently infected CD4+T cells and integrates with the host genome until cell death. Acquired immunodeficiency syndrome (AIDS) is associated with HIV-1.
Zhe-Sheng Chen, Fujun Peng
exaly +4 more sources
From Beginning to End: Expanding the SERINC3 Interactome Through an Analysis [PDF]
Bioinformatics and Biology Insights, 2022 The serine incorporator (SERINC) family of proteins are a family of multipass transmembrane proteins associated with biosynthesis of serine-containing phospholipids and sphingolipids.
Mckenzie Tu, Sarah Saputo
doaj +2 more sources
The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection [PDF]
Frontiers in Cell and Developmental Biology, 2022 Serine incorporator (SERINC) proteins 1–5 (SERINC1-5) are involved in the progression of several diseases. SERINC2-4 are carrier proteins that incorporate the polar amino acid serine into membranes to facilitate the synthesis of phosphatidylserine and ...
Shaofen Xu +12 more
doaj +2 more sources