Results 11 to 20 of about 701 (107)

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5

MBio, 2019
It has recently emerged that HIV-1 Nef counteracts the antiviral host proteins SERINC3 and SERINC5. In particular, SERINC5 inhibits the infectivity of progeny virions when incorporated.
Balaji Olety, Elena Popova, Heinrich Göttlinger   +2 more
exaly   +5 more sources

Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor

Viruses, 2015
The Nef protein is an accessory gene product encoded by human immunodeficiency virus types 1 and 2 (HIV-1/-2) and simian immunodeficiency virus (SIV) that boosts virus replication in the infected host and accelerates disease progression. Unlike the HIV-1
Oliver T Fackler
exaly   +4 more sources

Sinonasal adenosquamous carcinomas arising in seromucinous hamartoma or respiratory epithelial adenomatoid hamartoma with atypical features: Report of five detailed clinicopathological and molecular characterisation of rare entity. [PDF]

Histopathology
The tumour was covered by respiratory mucosa without metaplastic or dysplastic changes with branched glands of REAH descending from the surface respiratory epithelium into the stroma with budding structures of SH and ASGSH glands (A). Detailed SH transforming into ASGSH (B). AMP staining showing ASGSH with reduced brush border and mucin production (C).
Bradová M, Costes-Martineau V, Laco J, Vaněček T, Grossmann P, Němcová J, Pavlovský Z, Skálová A, Michal M.   +8 more
europepmc   +3 more sources

Identification of Diagnostically Relevant Biomarkers in Patients with Coronary Artery Disease by Comprehensive Analysis [PDF]

Journal of Inflammation Research
Zimin Wu,1,* Sisi Mo,2,* Zuyuan Huang,1 Baoshi Zheng1 1Department of Cardiovascular Surgery Ward, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China ...
Wu Z, Mo S, Huang Z, Zheng B
doaj   +4 more sources

Early brain-penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1-related Aicardi-Goutières syndrome. [PDF]

Clin Transl Immunology
Abstract Objectives Aicardi‐Goutières syndrome (AGS) is a genetic interferonopathy resulting from defects in nucleic acid metabolism and subsequent enhanced type I interferon signalling. We report how an expedited genomic diagnosis in conjunction with natural history data can enable a long‐term brain‐penetrant anti‐inflammatory regimen to optimise ...
Dale RC, Hayes J, Han VX, Dissanayake R, Lau X, Farrar M, Gloss B, Hofer M, Tantsis E, Lorentzos M, Abbas S, Crow YJ, Mohammad S, Patel S.   +13 more
europepmc   +2 more sources

CDCSI: a machine learning-based interpretable cell death and cellular senescence index for prognosis improvement, immune landscape characterization, and therapeutic response prediction in head and neck squamous cell carcinoma [PDF]

Frontiers in Immunology
BackgroundHead and neck squamous cell carcinoma (HNSCC) was characterized by pronounced heterogeneity and therapeutic resistance, which posed challenges for effective clinical management.
Xiaoqin Luo, Xian He
doaj   +2 more sources

Biochemical and Comparative Proteomic Analyses Delineate the Anti-Ovarian Carcinogenic Roles of Modified Calycosin. [PDF]

Food Sci Nutr
The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Yang F, Li X, Gao H, Yao P, Qin X, Lin X, Lai KP, Tian J, Chen J.   +8 more
europepmc   +2 more sources

SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation

Journal of Innate Immunity, 2020
Classical antiviral restriction factors promote cellular immunity by their ability to interfere with virus replication and induction of their expression by proinflammatory cytokines such as interferons.
Ariane Zutz, Christian Schölz, Stephanie Schneider, Virginia Pierini, Maximilian Münchhoff, Kathrin Sutter, Georg Wittmann, Ulf Dittmer, Rika Draenert, Johannes R. Bogner, Oliver T. Fackler, Oliver T. Keppler   +11 more
doaj   +2 more sources

SERINC Proteins Potentiate Antiviral Type I IFN Induction and Proinflammatory Signaling Pathways

Proceedings, 2020
T cell SERINC proteins were recently identified as human immunodeficiency virus (HIV) restriction factors that diminish viral infectivity by incorporation into virions.
Cong Zeng, Abdul A. Waheed, Tianliang Li, Jingyou Yu, Yi-Min Zheng, Jacob Yount, Haitao Wen, Eric O. Freed, Shan-Lu Liu   +8 more
doaj   +3 more sources

Serinc5 Regulates Sequential Chondrocyte Differentiation by Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes. [PDF]

J Cell Physiol
ABSTRACT The growth plate is the primary site of longitudinal bone growth with chondrocytes playing a pivotal role in endochondral bone development. Chondrocytes undergo a series of differentiation steps, resulting in the formation of a unique hierarchical columnar structure comprising round, proliferating, pre‐hypertrophic, and hypertrophic ...
Hata K, Wakamori K, Hirakawa-Yamamura A, Ichiyama-Kobayashi S, Yamaguchi M, Okuzaki D, Takahata Y, Murakami T, Uzawa N, Yamashiro T, Nishimura R.   +10 more
europepmc   +2 more sources