Results 21 to 30 of about 701 (107)
Altered memory CCR6+ Th17-polarised T-cell function and biology in people with HIV under successful antiretroviral therapy and HIV elite controllersResearch in context [PDF]
EBioMedicineSummary: Background: Despite successful antiretroviral therapy (ART), frequencies and immunological functions of memory CCR6+ Th17-polarised CD4+ T-cells are not fully restored in people with HIV (PWH).
Alexis Yero +11 more
doaj +2 more sources
Nef enhances HIV-1 replication and infectivity independently of SERINC5 in CEM T cells. [PDF]
Virology, 2023 A primary function of HIV-1 Nef is the enhancement of viral infectivity and replication. Whether counteraction of the antiretroviral proteins SERINC3 and SERINC5 is the cause of this positive influence on viral growth-rate and infectivity remains unclear.
Ramirez PW +7 more
europepmc +2 more sources
Prognostic Significance of Amino Acid Metabolism-Related Genes in Prostate Cancer Retrieved by Machine Learning [PDF]
Cancers, 2023 Ivana Samarzija +2 more
exaly +2 more sources
Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. [PDF]
EMBO J, 2021 Cells release diverse types of extracellular vesicles (EVs), which transfer complex signals to surrounding cells. Specific markers to distinguish different EVs (e.g. exosomes, ectosomes, enveloped viruses like HIV) are still lacking.
Martin-Jaular L +10 more
europepmc +2 more sources
SERINC5 Potently Restricts Retrovirus Infection
mBio, 2020 The serine incorporator (SERINC) proteins are multipass transmembrane proteins that affect sphingolipid and phosphatidylserine synthesis. Human SERINC5 and SERINC3 were recently shown to possess antiretroviral activity for a number of retroviruses ...
Uddhav Timilsina +4 more
doaj +1 more source
Journal of Cell Communication and Signaling, Volume 17, Issue 1, Page 121-135, March 2023., 2023 Abstract Although improved treatment could inhibit progression of gastric cancer (GC), the recurrence and metastasis remain challenging issues. Methyltransferase like 13 (METTL13) has been implicated in most human cancers, but its function and mechanism in GC remain elusive.
Qiong Wu +4 more
wiley +1 more source
Frontiers in Microbiology, 2020 Serine incorporator 3 (SERINC3) and SERINC5 were recently identified as host intrinsic factors against human immunodeficiency virus (HIV)-1 and counteracted by HIV-1 Nef.
Yue Liu +10 more
doaj +1 more source
Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022 By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari +4 more
wiley +1 more source
New target genes of MITF-induced microRNA-211 contribute to melanoma cell invasion. [PDF]
PLoS ONE, 2013 The non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns. They down-regulate target mRNAs, which likely impacts on most fundamental cellular processes. Differential expression patterns of miRNAs are currently being exploited
Christiane Margue +5 more
doaj +1 more source
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
Aging Cell, Volume 21, Issue 3, March 2022., 2022 A single cycle of transient OSKM activation in naturally aged mice is able to partially reverse age‐associated changes in several tissues. Specifically, we could capture reversion of alterations occurring with aging at the level of DNA methylation, transcription, as well as, serum metabolome.
Dafni Chondronasiou +16 more
wiley +1 more source