Results 41 to 50 of about 701 (107)

Attacking the Supply Lines: HIV-1 Restricts Alanine Uptake to Prevent T Cell Activation [PDF]

, 2015
HIV commonly escapes host antiviral immunity by downregulating cell-surface immunoreceptors. In a recent issue of Cell Host & Microbe, Matheson et al. (2015) systematically examined how HIV-1 infection remodels the T cell surface and identified serine ...
Sugden, Scott, Cohen, Éric A.
core   +1 more source

3D Bioprinted Coaxial Testis Model Using Human Induced Pluripotent Stem Cells:A Step Toward Bicompartmental Cytoarchitecture and Functionalization

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The ability of human induced pluripotent stem cells (hiPSCs) to model developmental processes makes them a promising source for engineering testicular tissues to study in vitro maturation and sperm production. This work describes the first hiPSC‐derived testicular model and shows that it captures functional aspects of prepubertal testicular tissues ...
Meghan A Robinson, Sonia HY Kung, Khaled YM Youssef, Kali M Scheck, Robert H Bell, Funda Sar, Anne M Haegert, M Mahdi Asmae, Changfeng Cheng, Salina V Yeack, Bhairvi T Mathur, Feng Jiang, Colin C Collins, Faraz Hach, Stephanie M Willerth, Ryan K Flannigan   +15 more
wiley   +1 more source

Proteomic Profiling of Extracellular Vesicles Reveals Potential Biomarkers for Helicobacter pylori Infection and Gastric Cancer

Helicobacter, Volume 30, Issue 2, March/April 2025.
ABSTRACT Background Helicobacter pylori (H. pylori) has been identified as a type I carcinogen and contributes to a high rate of gastric cancer (GC), especially in Eastern Asia. Extracellular vesicles (EVs) have the potential to be used to detect various cancer types and diseases. However, the protein markers in EVs for the prognosis of H.
Phawinee Subsomwong, Krisana Asano, Junko Akada, Takashi Matsumoto, Akio Nakane, Yoshio Yamaoka   +5 more
wiley   +1 more source

Supplementary Material for: SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation

, 2020
Classical antiviral restriction factors promote cellular immunity by their ability to interfere with virus replication and induction of their expression by proinflammatory cytokines such as interferons.
Sutter K. (8297262), Münchhoff M. (8297259), Keppler O.T. (8297280), Schölz C. (8297253), Draenert R. (8297271), Fackler O.T. (8297277), Zutz A. (8297250), Schneider S. (4125070), Wittmann G. (8297265), Bogner J.R. (8297274), Dittmer U. (8297268), Pierini V. (8297256)   +11 more
core   +1 more source

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang   +16 more
wiley   +1 more source

Manipulation of immunometabolism by HIV-accessories to the crime? [PDF]

, 2016
Evolutionary pressure has produced an 'arms race' between cellular restriction factors (limiting viral replication) and viral proteins (overcoming host restriction).
Paul J Lehner, Nicholas J Matheson, Edward JD Greenwood   +2 more
core   +2 more sources

Unveiling the molecular complexity of intestinal ischemia–reperfusion injury through omics technologies

PROTEOMICS, Volume 24, Issue 12-13, June 2024.
Abstract Intestinal ischemia–reperfusion injury (IR) is implicated in various clinical conditions and causes damage to the intestinal epithelium resulting in intestinal barrier loss. This presents a substantial clinical challenge, emphasizing the importance of gaining a comprehensive understanding of molecular events to aid in the identification of ...
Anja Alicehajic, Annet Adriana Maria Duivenvoorden, Kaatje Lenaerts   +2 more
wiley   +1 more source

LINC00355 promotes gastric carcinogenesis by scaffolding p300 to activate CDC42 transcription and enhancing HNRNPA2B1 to stabilize CDC42 mRNA dependent on m6A

Molecular Carcinogenesis, Volume 63, Issue 3, Page 430-447, March 2024.
Abstract LINC00355 is involved in the tumorigenesis of several types of cancer. We verified that LINC00355 is upregulated in gastric cancer (GC) and contributes to GC cells' proliferation and metastasis. RNA sequencing (RNA‐seq) and rescue assays suggested that LINC00355 controls gastric carcinogenesis by regulating the expression of cell division ...
Hui Chen, Lanshu Xiao, Guohua Xie, Peng Zhang, Ping Dong, Bingxian Bian, Jie Wang, Yunlan Zhou, Yanhui Ma, Yi Liu, Lisong Shen   +10 more
wiley   +1 more source

Alzheimer's disease‐induced phagocytic microglia express a specific profile of coding and non‐coding RNAs

Alzheimer's &Dementia, Volume 20, Issue 2, Page 954-974, February 2024.
Abstract INTRODUCTION Alzheimer's disease (AD) is a neurodegenerative disease and the main cause of dementia in the elderly. AD pathology is characterized by accumulation of microglia around the beta‐amyloid (Aβ) plaques which assumes disease‐specific transcriptional signatures, as for the disease‐associated microglia (DAM).
Flavia Scoyni, Luca Giudice, Mari‐Anna Väänänen, Nicholas Downes, Paula Korhonen, Xin Yi Choo, Nelli‐Noora Välimäki, Petri Mäkinen, Nea Korvenlaita, Annemieke J Rozemuller, Helga E de Vries, Jose Polo, Tiia A Turunen, Seppo Ylä‐Herttuala, Thomas B Hansen, Alexandra Grubman, Minna U Kaikkonen, Tarja Malm   +17 more
wiley   +1 more source

Perspective from single‐cell sequencing: Is inflammation in acute ischemic stroke beneficial or detrimental?

CNS Neuroscience &Therapeutics, Volume 30, Issue 1, January 2024.
Single‐cell sequencing reveals complex interactions of brain cells after acute ischemic stroke. After acute ischemic stroke, brain cells include microglia, astrocytes, peripheral blood macrophages, OPCs, oligodendrocytes, neutrophils, Th1 cells, CD8+ cells, B cells, NK cells, Treg cells, etc., cross‐talk with each other to participate in the disease ...
Xinpeng Deng, Ziliang Hu, Shengjun Zhou, Yiwen Wu, Menglin Fu, Chenhui Zhou, Jie Sun, Xiang Gao, Yi Huang   +8 more
wiley   +1 more source