Results 51 to 60 of about 701 (107)
, 2018 Protein trafficking in the endosomal system involves the recognition of specific signals within the cytoplasmic domains (CDs) of transmembrane proteins by clathrin adaptors.
Christopher Lim +8 more
core +1 more source
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A. [PDF]
, 2017 Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology.
Robinson, M. +23 more
core +2 more sources
HIV-1 infection: back and forth between virus and host. [PDF]
, 2020 The main obstacles to HIV-1 eradication are linked to the viral ability to evade immune system and establish a reservoir where virus is transcriptionally latent but able to replicate. IFN action and Restriction Factors (RFs) expression, dominant proteins
D'Urbano, Vanessa <1991>
core +1 more source
SIVcol Nef relocalizes SERINC5 to the proteasome by an Y86 dependent mechanism.
, 2018 (A) Representative Laser scanning confocal microscopy images of JTAg SERINC3/5 knock-out cells transfected with SERINC5–GFP (S5-GFP; green) alone or together with the indicated AU1-tagged Nef proteins (red). Endogenous lysosomes were stained with an anti-
Christina M. Stürzel (3752773) +16 more
core +1 more source
Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef. [PDF]
, 2015 Critical cell surface immunoreceptors downregulated during HIV infection have previously been identified using non-systematic, candidate approaches. To gain a comprehensive, unbiased overview of how HIV infection remodels the T cell surface, we took a ...
Weinelt, Julia +47 more
core +2 more sources
Rabbits as a model to study HIV-1 infection and the search for new innate immunity players in resting CD4 T cells [PDF]
, 2018 Once infected with human immunodeficiency virus (HIV), currently available pharmacotherapies can only partly control, but not cure infection. Thus, there remains an urgent need for more potent and conceptually novel antiviral therapeutics, including the ...
Baldauf, Hanna-Mari
core +1 more source
Identification of miR-211 target genes.
, 2013 (A) To identify new miR-211 target genes, miR-211-negative IGR39 melanoma cells were transfected with 5 nM miR-211 mimic or negative control (NCM) for 48 h.
Iris Behrmann (378331) +5 more
core +1 more source
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation
, 2016 HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on host membrane trafficking and receptor downregulation. By an unidentified mechanism, Nef increases the intrinsic infectivity of HIV-1 virions in a host-cell ...
Luban, Jeremy +11 more
core +1 more source
Host- and virus-mediated regulation of cell—cell fusion during HIV infection.
, 2017 A simplified schematic is shown of the events shaping HIV Env glycoprotein biosynthesis in the ER and Golgi and the numerous cellular factors encountered along the way.
Alex A. Compton (277055) +1 more
core +1 more source