Results 31 to 40 of about 109,824 (227)
Journal of Ginseng Research, 2017 Background: The presence of gross deletions in the human immunodeficiency virus nef gene (gΔnef) is associated with long-term nonprogression of infected patients.
Young-Keol Cho +2 more
doaj +1 more source
The nef cone volume of generalized Del Pezzo surfaces [PDF]
, 2007 We compute a naturally defined measure of the size of the nef cone of a Del Pezzo surface. The resulting number appears in a conjecture of Manin on the asymptotic behavior of the number of rational points of bounded height on the surface.
Derenthal, Ulrich +2 more
core +2 more sources
HIV-1 Nef Targets HDAC6 to Assure Viral Production and Virus Infection
Frontiers in Microbiology, 2019 HIV Nef is a central auxiliary protein in HIV infection and pathogenesis. Our results indicate that HDAC6 promotes the aggresome/autophagic degradation of the viral polyprotein Pr55Gag to inhibit HIV-1 production.
Sara Marrero-Hernández +17 more
doaj +1 more source
Viruses, 2021 Nef is a multifunctional viral protein that has the ability to downregulate cell surface molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as recently shown, also members of the serine incorporator family (SERINC).
Zita Kruize +6 more
doaj +1 more source
Nefs d’Or, Nefs d’Argent Between Space and Power
, 2022 The so-called nefs were an important ‘presence’ in the European courts starting from the Late Middle Ages. They were precious miniature ships, shown during banquets held in the halls of the nobility. In addition to delighting the sight of diners thanks to their ornamental richness, they were used as containers of spices, drinks, or luxury silverware ...
Andrea Missagia, Feliciano Tosetto
openaire +2 more sources
A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding. [PDF]
PLoS ONE, 2018 The HIV-1 Nef accessory protein is essential for viral pathogenicity and AIDS progression. Nef forms complexes with multiple host cell factors to facilitate viral replication and promote immune escape of HIV-infected cells.
Mousheng Wu +4 more
doaj +1 more source
Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41. [PDF]
PLoS Pathogens, 2011 Primate lentivirus nef is required for sustained virus replication in vivo and accelerated progression to AIDS. While exploring the mechanism by which Nef increases the infectivity of cell-free virions, we investigated a functional link between Nef and ...
Rachel P J Lai +6 more
doaj +1 more source
Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins. [PDF]
, 2019 The plasma membrane is a site of conflict between host defenses and many viruses. One aspect of this conflict is the host's attempt to eliminate infected cells using innate and adaptive cell-mediated immune mechanisms that recognize features of the ...
Guatelli, John +5 more
core +1 more source
A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.
PLoS ONE, 2015 To find out new determinants required for Nef activity we performed a functional alanine scanning analysis along a discrete but highly conserved region at the core of HIV-1 Nef.
Marta Martínez-Bonet +7 more
doaj +1 more source
Exosomes are unlikely involved in intercellular Nef transfer. [PDF]
PLoS ONE, 2015 HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Several recent studies including ours have demonstrated that Nef can be transferred to neighboring cells and alters the function of these cells.
Xiaoyu Luo +3 more
doaj +1 more source