Results 81 to 90 of about 109,824 (227)

High levels of anti‐Nef antibodies may prevent AIDS disease progression in vertically HIV‐1‐infected infants

Journal of the International AIDS Society, 2014
Introduction HIV‐1‐associated CD4+ T‐cell depletion is a consequence of uninfected cell death. Nef is one of the viral factors that trigger apoptosis on bystander cells, though the plasma Nef levels do not correlate with Th lymphocytes counts. The aim of
Guillermo Corró, Cintia Milena Crudeli, Carlos Alberto Rocco, Silvia Alejandra Marino, Luisa Sen   +4 more
doaj   +1 more source

Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2

Retrovirology, 2011
Background The HIV-1 accessory protein Nef is an important determinant of lentiviral pathogenicity that contributes to disease progression by enhancing viral replication and other poorly understood mechanisms.
Olivieri Kevin C, Mukerji Joya, Gabuzda Dana   +2 more
doaj   +1 more source

PLGA/BGP/Nef porous composite restrains osteoclasts by inhibiting the NF-κB pathway, enhances IGF-1-mediated osteogenic differentiation and promotes bone regeneration [PDF]

, 2023
Feng Wu, Zhenxu Wu, Zhijun Ye, Guoqing Niu, Zhiliang Ma, Peibiao Zhang   +5 more
openalex   +1 more source

Molecular Determinants of Nef Function

Journal of Biomedical Science, 1997
The human immunodeficiency virus (HIV), the causative agent of the acquired immune deficiency syndrome (AIDS), in addition to encoding for the gag, pol and env structural genes common to all retroviruses also encodes six accessory genes: tat, rev, nef, vpr, vpu and vif. These accessory genes are responsible for the regulation of HIV replication. Recent
T., Luo, J.L., Foster, J.V., Garcia
openaire   +2 more sources

HIV-1 nef suppression by virally encoded microRNA

Retrovirology, 2004
Background MicroRNAs (miRNAs) are 21~25-nucleotides (nt) long and interact with mRNAs to trigger either translational repression or RNA cleavage through RNA interference (RNAi), depending on the degree of complementarity with the target mRNAs. Our recent
Brisibe Ebiamadon, Okuyama Harumi, Ichikawa Yuko, Tsutsumi Yutaka, Ito Masafumi, Omoto Shinya, Saksena Nitin K, Fujii Yoichi R   +7 more
doaj   +1 more source

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

mBio, 2016
HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8+ T cells.
Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D. Walker, Yong Xiong, Zabrina L. Brumme, Mark A. Brockman, Takamasa Ueno   +10 more
doaj   +1 more source

On generic nefness of tangent sheaves [PDF]

, 2023
Wenhao Ou
openalex   +1 more source

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization

Scientific Reports, 2017
HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef. Using
Alexandra Boeske, Melanie Schwarten, Peixiang Ma, Markus Tusche, Jessica Mötter, Christina Möller, Philipp Neudecker, Silke Hoffmann, Dieter Willbold   +8 more
doaj   +1 more source

Rational nef and anti-nef polytopes are not uniform

, 2021
We give two examples which show that rational nef and anti-nef polytopes are not uniform even for klt surface pairs, answering a question of Chen-Han. We also show that rational nef polytopes are uniform when the Cartier indices are uniformly bounded.
openaire   +2 more sources

Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction.

PLoS ONE, 2014
With effective antiretroviral therapy (ART), cardiovascular diseases (CVD) are emerging as a major cause of morbidity and death in the aging HIV-infected population.
Ting Wang, Linden A Green, Samir K Gupta, Chul Kim, Liang Wang, Sharilyn Almodovar, Sonia C Flores, Igor A Prudovsky, Paul Jolicoeur, Ziyue Liu, Matthias Clauss   +10 more
doaj   +1 more source