Results 131 to 140 of about 318,238 (318)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Questions and Answers about Oppositions [PDF]

open access: yes, 2011
A general characterization of logical opposition is given in the present paper, where oppositions are defined by specific answers in an algebraic question-answer game. It is shown that opposition is essentially a semantic relation of truth values between
Schang, Fabien
core  

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The Potential of Negation Questions for Affecting the Audience in Dehkhoda's Amsal-o-Hekam [PDF]

open access: yesLiterary Arts
The negation question is one of the rhetorical questions that are widely used in language and literature. Poets and writers use it according to the situation to persuade the audience.
Zohre Ahmadipooranari   +2 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Способы выражения отрицания в балтийских и славянских языках (на материале русского и литовского языков)

open access: yesBaltistica, 2011
THE WAYS OF EXPRESSING NEGATION IN BALTIC AND SLAVIC LANGUAGESSummaryThe paper is concerned with negation as the universality of language. The content of the given category is determined, and the two ways of its expression in the Russian and Lithuanian ...
Елена Генриховна Казимянец
doaj   +1 more source

Negation

open access: yesAnalytica - Revista de Filosofia, 2023
A negação, no Tractatus, não pode ser tratada como um conceito, tal como acontecia em Frege e em Russell. Se isto acontecesse, p e ~~p deveriam ter sentidos composicionalmente diferentes. A negação não pode se resumir a uma relação lógica entre dois enunciados, pois ~p deve ser construída a partir de p, e não o contrário.
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

The syntax of emphatic negation in Modern Irish

open access: yesGlossa
In this paper I argue, following proposals by Laka (1990), Aboh (2010), De Clercq (2013; 2020a), and Greco (2019; 2020ab) among others, that negation has a dedicated position in the left periphery where it takes wide scope over the lower sentential ...
Nicola D'Antuono
doaj   +2 more sources

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