Results 291 to 300 of about 121,181 (303)

DSR-98776, a novel selective mGlu5 receptor negative allosteric modulator with potent antidepressant and antimanic activity

European Journal of Pharmacology, 2015
Taro Kato, Atsuto Inoue, Chihiro Ishikawa   +2 more
exaly  

In vitro and in vivo characterization of a novel negative allosteric modulator of neuronal nAChRs

Neuropharmacology, 2010
Galya R Abdrakhmanova, Bruce E Blough, Hernán A Navarro   +2 more
exaly  

Discovery of ONO-8590580: A novel, potent and selective GABAA α5 negative allosteric modulator for the treatment of cognitive disorders

Bioorganic and Medicinal Chemistry Letters, 2020
exaly  

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator

Bioorganic and Medicinal Chemistry Letters, 2013
Junliang Hao, Thomas C Britton, Edda F Roberts   +2 more
exaly  

Discovery of a Negative Allosteric Modulator of GABAB Receptors

ACS Medicinal Chemistry Letters, 2014
Linhai Chen, Bing Sun, Jianfeng Liu
exaly  

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D 2 receptor

Biochemical Pharmacology, 2018
Mayako Michino, Carmen Klein Herenbrink, Jeremy Shonberg   +2 more
exaly  

Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2

ACS Chemical Neuroscience, 2017
Katsushi Kumata, Akiko Hatori, Longle Ma   +2 more
exaly  

Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications.

Journal of Medicinal Chemistry, 2017
J. Galambos, A. Bielik, M. Krasavin, Z. Orgován, G. Domány, K. Nógrádi, G. Wágner, G. Balogh, Z. Béni, J. Kóti, Z. Szakács, A. Bobok, S. Kolok, Mónika L Mikó-Bakk, M. Vastag, K. Sághy, J. Laszy, A. Halász, Ottilia Balázs, Krisztina Gál, I. Greiner, Z. Szombathelyi, G. Keserű   +22 more
semanticscholar   +1 more source

A Phase 2A Trial of the Novel mGluR5‐Negative Allosteric Modulator Dipraglurant for Levodopa‐Induced Dyskinesia in Parkinson's Disease

Movement Disorders, 2016
F. Tison, C. Keywood, Mark Wakefield, F. Durif, J. Corvol, K. Eggert, M. Lew, S. Isaacson, E. Bézard, S. Poli, C. Goetz, C. Trenkwalder, O. Rascol   +12 more
semanticscholar   +1 more source

Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain

Cell
Shaoyong Song, Michael R Jackson, Ru-Rong Ji   +2 more
exaly