Results 71 to 80 of about 1,617,958 (348)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Conceptual design of the beam source for the DEMO Neutral Beam Injectors

New Journal of Physics, 2016
DEMO (DEMOnstration Fusion Power Plant) is a proposed nuclear fusion power plant that is intended to follow the ITER experimental reactor. The main goal of DEMO will be to demonstrate the possibility to produce electric energy from the fusion reaction ...
P Sonato, P Agostinetti, U Fantz, T Franke, I Furno, A Simonin, M Q Tran   +6 more
doaj   +1 more source

Recent Negative Ion Source Developments [PDF]

IEEE Transactions on Nuclear Science, 1979
This report describes recent results obtained from studies associated with the development of negative ion sources which utilize sputtering in a diffuse cesium plasma as a means of ion beam generation. Data are presented which relate negative ion yield and important operational parameters such as cesium oven temperature and sputter probe voltage from ...
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Conceptional design of photoneutralization test system for negative ion-based neutral beam injection

Nuclear Engineering and Technology
Neutral beam injection is one of the effective heating methods in the field of magnetic confinement fusion, and neutralization is the most crucial link in the case of negative ions.
Hui-hui Hong, Li-zhen Liang, Yuan-lai Xie, Qian-xu Wang, Zhuo Pan, Yao Jiang   +5 more
doaj   +1 more source

Negative-ion source applications (invited) [PDF]

Review of Scientific Instruments, 2008
In this paper heavy negative-ion sources which we developed and their applications for materials science are reviewed. Heavy negative ions can be effectively produced by the ejection of a sputtered atom through the optimally cesiated surface of target with a low work function.
openaire   +1 more source

Experimental evaluation of a negative-ion source for a heavy-ion fusion negative-ion driver [PDF]

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2005
Abstract Negative halogen ions have recently been proposed as a possible alternative to positive ions for heavy-ion fusion drivers because electron accumulation would not be a problem in the accelerator, and if desired, the beams could be photodetached to neutrals (Nucl. Instr. and Meth. A 464 (2001) 315; Fusion Sci. Technol.
Grisham, L. R., Hahto, S. K., Hahto, S. T., Kwan, J. W., Leung, K. N.   +4 more
openaire   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Three-dimensional fluid simulation of radio-frequency negative hydrogen ion source with the addition of noble gases

Nuclear Fusion
As an essential part of the neutral beam injection system for the magnetic confinement fusion devices, radio-frequency (RF) ion source is responsible for generating negative hydrogen ions.
Chao Chen, Ning Liu, Miao Zhao, Guangjiu Lei, Dongping Liu, Xianjun Sheng   +5 more
doaj   +1 more source