Results 71 to 80 of about 427,941 (305)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

FAST NEGATIVE HYDROGEN IONS

, 1954
A proton beam was directed through hydrogen gas at low pressure and magnetic analysis of the emergent beam showed that an appreciable fraction of the beam was transformed into negative hydrogen ions.
A. Charles Whittier
core   +1 more source

Negative Ions of Polyatomic Molecules

Environmental Health Perspectives, 1980
In this paper general concepts relating to, and recent advances in, the study of negative ions of polyatomic molecules area discussed with emphasis on halocarbons. The topics dealt with in the paper are as follows: basic electron attachment processes, modes of electron capture by molecules, short-lived transient negative ions, dissociative electron ...
openaire   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Detecting negative ions on board small satellites [PDF]

, 2017
Recent measurements near comets, planets, and their satellites have shown that heavy ions, energetic neutral atoms, molecular ions, and charged dust contain a wealth of information about the origin, evolution, and interaction of celestial bodies with ...
M. Panning, Cutler, J., J. Cutler, Zurbuchen, T. H., Raines, J. M., J. A. Gilbert, Gilbert, J. A., T. H. Zurbuchen, S. T. Lepri, J. M. Raines, Panning, M., Lepri, S. T.   +11 more
core   +1 more source

Ionic diffusion into the peripheral area of a glow discharge in the electronegative gases

St. Petersburg Polytechnical University Journal: Physics and Mathematics
In the paper, the effect of negative ion diffusive penetration from the central space representing the ion-ion plasma on the electron-ion plasma located in the peripheral area of a positive column of a glow discharge in the strong electronegative gases ...
Golovitskii Alexander
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Beware of negative ‘IONs’

, 2013
The title appears to be about science teaching but, don’t be fooled, it isn’t. This article takes a look at the fashions and soundbites that underpin policy and practice in relation to learners experiencing barriers to their participation and achievement
Blamires, M.
core  

Recent experimental achievements with negative ions

, 1995
International audienceExperimental results obtained about the atomic physics of negative ions since the Physica Scripta 1991 review are presented. Most new data concern the metastable states and resonances of He- and alkaline-earth negative ions, and ...
Blondel, C.
core   +1 more source