Results 31 to 40 of about 4,598,204 (290)
Early-life homeostatic differentiation of thymus-resident B cells into memory B cells
Frontiers in ImmunologyThe thymus contains various antigen-presenting cells, including B cells, which remain activated even under steady-state conditions, suggesting ongoing local stimulation. In this study, we identify class-switched memory B cells in the thymus.
Justine Castañeda +11 more
doaj +1 more source
Molecular Evolution of the Protease Region in Norovirus Genogroup II
Frontiers in Microbiology, 2020 Noroviruses are a major cause of viral epidemic gastroenteritis in humans worldwide. The protease (Pro) encoded in open reading frame 1 (ORF1) is an essential enzyme for proteolysis of the viral polyprotein.
Keita Ozaki +13 more
doaj +1 more source
Optimal securities under adverse selection and moral hazard [PDF]
, 2009 We consider project financing under adverse selection and moral hazard and derive several interesting results. First, we provide an explanation of why good firms issue both debt and underpriced equity (even if the bankruptcy and agency costs of debt are ...
Koufopoulos, Kostas
core +1 more source
Negative Clonal Selection in Tumor Evolution [PDF]
Genetics, 2005 Abstract Development of cancer requires the acquisition of multiple oncogenic mutations and selection of the malignant clone. Cancer evolves within a finite host lifetime and mechanisms of carcinogenesis that accelerate this process may be more likely to contribute to the development of clinical cancers.
Robert A, Beckman, Lawrence A, Loeb
openaire +2 more sources
Communications, 2016 The problem of development automation of classification rules synthesis on the basis of negative selection in the case of uneven distribution of classes in the sample is solved.
Sergey Subbotin +3 more
doaj +1 more source
Frontiers in Microbiology, 2020 Influenza A virus (IAV) causes seasonal infections and periodic pandemics in humans. The non-structural protein 1 (NS1) of IAV is the main viral antagonist of the innate immune responses that play a key role in influenza pathogenesis.
Hua Wang +5 more
doaj +1 more source
Effect of sources of sweetpotato planting material for quality vine and root yield
Open Agriculture, 2017 Commercialization of sweetpotato vines is persistent if multipliers show evidence of superiority of their vines. This study aimed at evaluating the effects of net tunnel source and of pathogen-tested planting material compared to “apparently” healthy ...
Abidin Putri E. +4 more
doaj +1 more source
Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection [PDF]
, 2020 The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Loll, Bernhard +3 more
core +1 more source
Thymic crosstalk coordinates medulla organization and T-cell tolerance induction
Frontiers in Immunology, 2015 The thymus ensures the generation of a functional and highly diverse T-cell repertoire. The thymic medulla, which is mainly composed of medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), provides a specialized microenvironment dedicated
Noëlla eLopes +3 more
doaj +1 more source
Self-selection patterns in Mexico-U.S. migration: the role of migration networks [PDF]
, 2007 This paper examines the role of migration networks in determining self-selection patterns of Mexico-U.S. migration. We first present a simple theoretical framework showing how such networks impact on migration incentives at different education levels ...
McKenzie, D., Rapoport, H.
core +1 more source