Results 1 to 10 of about 70,818 (259)

Horizontal Gene Transfer of Fluoroquinolone Resistance-Conferring Genes From Commensal Neisseria to Neisseria gonorrhoeae: A Global Phylogenetic Analysis of 20,047 Isolates

Frontiers in Microbiology, 2022
Antimicrobial resistance in Neisseria gonorrhoeae is an important global health concern. The genetically related commensal Neisseria act as a reservoir of resistance genes, and horizontal gene transfer (HGT) has been shown to play an important role in ...
Sheeba Santhini Manoharan-Basil, Natalia González, Jolein Gyonne Elise Laumen, Chris Kenyon, Chris Kenyon   +4 more
doaj   +2 more sources

Evidence of Horizontal Gene Transfer of 50S Ribosomal Genes rplB, rplD, and rplY in Neisseria gonorrhoeae

Frontiers in Microbiology, 2021
Horizontal gene transfer (HGT) in the penA and multidrug efflux pump genes has been shown to play a key role in the genesis of antimicrobial resistance in Neisseria gonorrhoeae. In this study, we evaluated if there was evidence of HGT in the genes coding
Sheeba Santhini Manoharan-Basil, Jolein Gyonne Elise Laumen, Jolein Gyonne Elise Laumen, Christophe Van Dijck, Christophe Van Dijck, Tessa De Block, Irith De Baetselier, Chris Kenyon, Chris Kenyon   +8 more
doaj   +2 more sources

Research progress on new antibiotics in the treatment of Neisseria gonorrhoeae infection [PDF]

Xin yixue, 2022
Neisseria gonorrhoeae is the pathogen of gonorrhea. With the widespread use of antibiotics, drug resistance of Neisseria gonorrhoeae is a growing problem.
Zhong Jiaojiao, Su Xiaohong
doaj   +1 more source

Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2022
We describe a gonorrhoea case with ceftriaxone plus high-level azithromycin resistance. In April 2022, an Austrian heterosexual male was diagnosed with gonorrhoea after sexual intercourse with a female sex worker in Cambodia.
S. Pleininger, A. Indra, D. Golparian, F. Heger, S. Schindler, S. Jacobsson, S. Heidler, M. Unemo   +7 more
semanticscholar   +1 more source

A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch

Genome Medicine, 2021
Antimicrobial-resistant (AMR) Neisseria gonorrhoeae is an urgent threat to public health, as strains resistant to at least one of the two last-line antibiotics used in empiric therapy of gonorrhoea, ceftriaxone and azithromycin, have spread ...
Leonor Sánchez-Busó, C. Yeats, Ben Taylor, Richard J. Goater, A. Underwood, Khalil AbuDahab, S. Argimón, K. C. Ma, T. D. Mortimer, D. Golparian, M. Cole, Y. Grad, I. Martin, Brian H. Raphael, W. Shafer, K. Town, T. Wi, S. Harris, M. Unemo, D. Aanensen   +19 more
semanticscholar   +1 more source

Structure-Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae.

ACS Infectious Diseases, 2021
Neisseria gonorrhoeae is an urgent threat to public health in the United States and around the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are quickly becoming obsolete due to increased rates of resistance.
Chad S. Hewitt, Nader S. Abutaleb, Ahmed E. M. Elhassanny, A. Nocentini, Xufeng Cao, Devon P Amos, Molly S Youse, Katrina J Holly, A. K. Marapaka, Weiwei An, J. Kaur, Aaron D. Krabill, Ahmed Elkashif, Y. Elgammal, Amanda L. Graboski, C. Supuran, M. Seleem, D. Flaherty   +17 more
semanticscholar   +1 more source

Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence of resistance development against approved antibiotics. Herein, we report the anti-gonococcal activity of ethoxzolamide, the FDA-approved human carbonic anhydrase ...
Nader S. Abutaleb, Ahmed E. M. Elhassanny, A. Nocentini, Chad S. Hewitt, Ahmed Elkashif, B. Cooper, C. Supuran, M. Seleem, D. Flaherty   +8 more
semanticscholar   +1 more source

Choosing New Therapies for Gonorrhoea: We Need to Consider the Impact on the Pan-Neisseria Genome. A Viewpoint

Antibiotics, 2021
The development of new gonorrhoea treatment guidelines typically considers the resistance-inducing effect of the treatment only on Neisseria gonorrhoeae. Antimicrobial resistance in N.
Chris Kenyon, Jolein Laumen, Sheeba Manoharan-Basil   +2 more
doaj   +1 more source

Neisseria mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae

Sci, 2022
Antibiotic-sparing treatments are required to prevent the further emergence of antimicrobial resistance in Neisseria gonorrhoeae. Commensal Neisseria species have previously been found to inhibit the growth of pathogenic Neisseria species. For example, a
Saïd Abdellati, Jolein Laumen, Natalia Gonzalez, Sheeba S. Manoharan-Basil, Christophe Van Dijck, Irith De Baetselier, Delphine Martiny, Tessa de Block, Chris Kenyon   +8 more
doaj   +1 more source

Antimicrobial Resistance Profiles of Human Commensal Neisseria Species

Antibiotics, 2021
Pathogenic Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhea. N. gonorrhoeae has evolved high levels of antimicrobial resistance (AR) leading to therapeutic failures even in dual-therapy treatment with azithromycin and ceftriaxone.
Maira Goytia, Symone T. Thompson, Skylar V. L. Jordan, Kacey A. King   +3 more
doaj   +1 more source