Results 51 to 60 of about 34,038 (225)

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Two Sides of the Same Coin—Mechanistic Insight, Diagnostic Application and Therapeutic Translation of Bacterial and Host‐Derived Extracellular Vesicles

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Extracellular vesicles (EVs) have gained increasing attention in recent years due to their pivotal role in both health and disease. Emerging from both eukaryotic and prokaryotic cells, EVs serve as essential mediators of intercellular communication, exceeding the simplistic interactions observed with individual molecules. In this comprehensive
Philipp Arnold, Fanni Annamária Boros, Jochen Mattner, Gerald Seidel, Chaofan Liu, Inga Viktoria Hensel, Jan Van Deun, Raphael Schwendner, Janina Müller‐Deile, Nina Sopel, Andreas Ramming, Mario R. Angeli, Simon Rauber, Cláudia Vilhena, Andreas Baur, Stefan Wirtz, Klaus Überla, Heiko Reutter, Linda‐Marie Mulzer, Alina C. Hilger, Friederike Zunke, Wei Xiang, Gregor Fuhrmann, Claudia Günther   +23 more
wiley   +1 more source

Oral Microbiota Linking Humoral Response, Periodontitis and Atherosclerosis

Journal of Clinical Periodontology, Volume 52, Issue 11, Page 1550-1559, November 2025.
ABSTRACT Aim The humoral immune system is implicated in the link between periodontitis and atherosclerosis. This study aims to explore how interactions between the oral microbiota and humoral immune responses may contribute to this association. Materials and Methods We analysed data from the Northern Finland Birth Cohort 1966, which included 1560 ...
Ramin Akhi, Anton Lavrinienko, Miia Hakula, Rasmus Hindström, Chunguang Wang, Antti Nissinen, Arja M. Kullaa, Tuula Salo, Kari Kaikkonen, Tellervo Tervonen, Pekka Ylöstalo, Janne J. Koskimäki, Sohvi Hörkkö   +12 more
wiley   +1 more source

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Annals of Neurology, Volume 98, Issue 4, Page 851-863, October 2025.
Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, I‐PACE Study Group, Diederik van de Beek, Matthijs C. Brouwer   +7 more
wiley   +1 more source

Generalized Tetanus Associated With Malaria and Probable Meningitis in a 4‐Year‐Old Patient: A Case Report in Limbe Regional Hospital, Cameroon

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Tetanus is a life‐threatening disease preventable by immunization through vaccines. In resource‐limited settings, its association with other acute infections should be managed cautiously. A 4‐year‐old unvaccinated male was referred from a nearby hospital for better management of severe malaria and probable enteric fever, after presenting there
Christian Damien Tchuisseu Ngapjang, Christian Fotso, Ronald Gobina, Philippe Albert Lingo, Quincy‐Jones Shumbang Tchumukong, Bertold Brecht Kouam, Marc Effila, Emelinda Berinyuy Nyuydzefon, Verla Vincent Siysi   +8 more
wiley   +1 more source

Cases of Neisseria meningitidis in Greece

Eurosurveillance, 1997
In Greece, Neisseria meningitidis appears as sporadic cases with some seasonal local outbreaks. The notification of meningococcal disease to the local health authorities and the Ministry of Health is mandatory.
Georgina Tzanakaki, N Vakalis, A Velonaki, Jenny Kremastinou   +3 more
openaire   +3 more sources

Development of a Promising Bivalent Vaccine Against Klebsiella pneumoniae Based on Glycoengineered GMMA (geGMMA)

Exploration, Volume 5, Issue 5, October 2025.
Multidrug‐resistant Klebsiella pneumoniae poses a significant threat as a nosocomial pathogen, with no current licensed vaccines available. This study used a mutant E. coli strain expressing exogenous polysaccharides (from K. pneumoniae) to establish glycoengineered generalized modules for membrane antigens (geGMMA) vaccine platform, which demonstrated
Jingqin Ye, Wenhua Huang, Shujuan Yu, Yan Guo, Peng Sun, Ziyuan Chen, Linhui Hao, Yan Zhang, Caixia Li, Yongqiang Jiang, Jun Wu, Li Zhu, Hengliang Wang, Chao Pan   +13 more
wiley   +1 more source

Bacterial antigen detection in cerebrospinal fluid by the latex agglutination test Detecção de antígenos bacterianos no líquido cefalorraquidiano através do teste de aglutinação de latex

Revista do Instituto de Medicina Tropical de São Paulo, 1995
Eighty purulent cerebrospinal fluid (CSF) samples from patients with clinical evidence of meningitis were studied using the Directigen latex agglutination (LA) kit to determine the presence of bacterial antigen in CSF.
Ilka Maria Landgraf, Maria das Graças Adelino Alkmin, Maria de Fátima Paiva Vieira   +2 more
doaj   +1 more source

Organism resembling Neisseria gonorrhoeae and Neisseria meningitidis [PDF]

Journal of Clinical Microbiology, 1987
A problem isolate resembling Neisseria gonorrhoeae and Neisseria meningitidis is reported. Growth and biochemical characteristics indicated the organism to be N. meningitidis, whereas serological characteristics indicated it to be N. gonorrhoeae. This vaginal isolate may be a genetically transformed gonococcus with the ability to utilize maltose ...
A S Ali, D S Hodge, F E Ashton, R Terro
openaire   +2 more sources

Generalized Modules for Membrane Antigens (GMMA) Elicit Mild Local Reactogenicity After Intramuscular Injection in Absence of Aluminum Salt Adjuvant

Immunity, Inflammation and Disease, Volume 13, Issue 10, October 2025.
ABSTRACT Background and Objectives Generalized modules for membrane antigens (GMMA) are outer membrane vesicles derived from gram‐negative bacteria that can be used to design affordable subunit vaccines. GMMA are highly immunogenic and capable to induce an optimal antigen‐specific humoral immune response both in animals and humans. Despite their potent
Raffaella Cecchi, Silvia Maccari, Renzo Alfini, Roberta Di Benedetto, Simona Gallorini, Elena Cartocci, Sara Marchi, Giacomo Romagnoli, Erika Bartolini, Francesca Micoli, Diego Piccioli   +10 more
wiley   +1 more source