Results 71 to 80 of about 29,293 (218)

Safety of Avacopan for the Treatment of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Combined Data From Three Clinical Trials

ACR Open Rheumatology, Volume 7, Issue 4, April 2025.
Objective This study aimed to report the safety of avacopan, an oral selective complement C5a receptor antagonist, using pooled data from clinical trials in patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (granulomatosis with polyangiitis [GPA] or microscopic polyangiitis [MPA]).
Peter A. Merkel, Michael D. George, Huibin Yue, Tamara Popov, Andreas Kronbichler, Mark A. Little, David R.W. Jayne   +6 more
wiley   +1 more source

Escherichia coli in the production of biopharmaceuticals

Biotechnology and Applied Biochemistry, Volume 72, Issue 2, Page 528-541, April 2025.
Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley   +1 more source

A cross-sectional study assessing the pharyngeal carriage of Neisseria meningitidis in subjects aged 1–24 years in the city of Embu das Artes, São Paulo, Brazil

Brazilian Journal of Infectious Diseases, 2017
Meningococcal carriage is a prerequisite for invasive infection. This cross-sectional study assessed the pharyngeal carriage prevalence in healthy subjects aged 1–24 years in Embu das Artes city, São Paulo, Brazil.
Lily Yin Weckx, Rosana Fiorini Puccini, Antónia Machado, Maria Gisele Gonçalves, Suely Tuboi, Eliana de Barros, Raghavendra Devadiga, Eduardo Ortega-Barria, Romulo Colindres   +8 more
doaj  

Orogenital Transmission of Neisseria meningitidis Causing Acute Urethritis in Men Who Have Sex with Men

Emerging Infectious Diseases, 2019
Neisseria meningitidis sequence type 11 is an emerging cause of urethritis. We demonstrate by using whole-genome sequencing orogenital transmission of a N.
Arnaud Jannic, Hedi Mammeri, Lise Larcher, Vincent Descamps, William Tosini, Bao Phung, Yazdan Yazdanpanah, Fabrice Bouscarat   +7 more
doaj   +1 more source

Hydrocephalus and Cerebral Small Vessel Disease in an Adult With Meningococcal Meningitis and Dilated Cardiomyopathy: A Fatal Outcome

Clinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT Meningococcal meningitis can lead to serious neurological complications such as hydrocephalus directly and contribute to cerebral small vessel disease indirectly, especially in patients with pre‐existing conditions like dilated cardiomyopathy.
Yousif Mohamed, Ahmed Mohamed, Abubaker Elemam, Abubaker Babiker   +3 more
wiley   +1 more source

Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection

Nature Communications, 2018
Carriage of Neisseria lactamica, a harmless coloniser of the human respiratory tract, is inversely correlated with Neisseria meningitidis infection. Here, Pandey et al. provide insights into micro-evolutionary processes in N.
Anish Pandey, David W. Cleary, Jay R. Laver, Andrew Gorringe, Alice M. Deasy, Adam P. Dale, Paul D. Morris, Xavier Didelot, Martin C. J. Maiden, Robert C. Read   +9 more
doaj   +1 more source

Meningococcal Vaccines: Challenges and Prospects

Vaccines, 2020
Neisseria meningitidis is a gram-negative bacterium that causes a severe acute infection, called the meningococcal disease [...]
Priyal Bagwe, Lotika Bajaj, Rikhav Gala, Susu M. Zughaier, Mohammad N. Uddin, Martin J. D’Souza   +5 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Avner Sandhu, Tong Shen, Paz Martin Herrero, Chao‐Xing Yuan, Samirah Qureshi, Xiaoyu Jiang, Ye Sheng, Christoph Gasteyger, Yang Dai   +8 more
wiley   +1 more source

α-2,3-Sialyltransferase Expression Level Impacts the Kinetics of Lipooligosaccharide Sialylation, Complement Resistance, and the Ability of Neisseria gonorrhoeae to Colonize the Murine Genital Tract

mBio, 2015
Neisseria meningitidis and Neisseria gonorrhoeae modify the terminal lacto-N-neotetraose moiety of their lipooligosaccharide (LOS) with sialic acid. N.
Lisa A. Lewis, Sunita Gulati, Elizabeth Burrowes, Bo Zheng, Sanjay Ram, Peter A. Rice   +5 more
doaj   +1 more source

Long‐Term Efficacy and Safety of Ravulizumab in Adults With Anti‐Acetylcholine Receptor Antibody‐Positive Generalized Myasthenia Gravis: Final Results From the Phase 3 CHAMPION MG Open‐Label Extension

European Journal of Neurology, Volume 32, Issue 4, April 2025.
Ravulizumab demonstrated clinically meaningful and durable efficacy and safety in adults with anti‐acetylcholine receptor antibody‐positive generalized myasthenia gravis in the CHAMPION MG open‐label extension (OLE) study. Improvements from baseline in MG‐ADL, QMG, and MG‐QOL15r total scores, and the NeuroQOL Fatigue subscale scores achieved in ...
Tuan H. Vu, Renato Mantegazza, Djillali Annane, Masahisa Katsuno, Andreas Meisel, Michael W. Nicolle, Vera Bril, Rasha Aguzzi, Glen Frick, James F. Howard Jr, the CHAMPION MG Study Group   +10 more
wiley   +1 more source