Results 91 to 100 of about 30,793 (265)

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Table_1_Untranslated regions (UTRs) are a potential novel source of neoantigens for personalised immunotherapy.xlsx

BackgroundNeoantigens, mutated tumour-specific antigens, are key targets of anti-tumour immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to designing neoantigen-directed therapy.
Christopher C. T. Sng (7773827), Georges Bedran (15160747), Javier Alfaro (15160759), Ashwin Adrian Kallor (7840853), Kevin Litchfield (8318559), Benjamin S. Simpson (8550819)   +5 more
core   +1 more source

Table_3_A Comprehensive Survey of Genomic Mutations in Breast Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.xlsx

, 2022
Neoantigens are mutated antigens specifically generated by cancer cells but absent in normal cells. With high specificity and immunogenicity, neoantigens are considered as an ideal target for immunotherapy.
Lijian Zhao (5734019), Hai-Xi Sun (9499079), Songming Liu (12267134), Si Zhou (669724)   +3 more
core   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

From the Dark Genome to Immunotherapy Targets: Artificial Intelligence Enables the Identification of Noncanonical Neoantigens

Research
Emerging evidence has demonstrated that a previously defined dark genome might encode short peptides that bind human leukocyte antigen as noncanonical antigens to activate immunity.
Juan Xu, Yangyang Cai, Jiyu Guo, Dezhong Lv, Yingying Ma, Wenjun Mao, Qinghua Jiang, Yongsheng Li   +7 more
doaj   +1 more source

Table_2_Untranslated regions (UTRs) are a potential novel source of neoantigens for personalised immunotherapy.xlsx

BackgroundNeoantigens, mutated tumour-specific antigens, are key targets of anti-tumour immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to designing neoantigen-directed therapy.
Christopher C. T. Sng (7773827), Georges Bedran (15160747), Javier Alfaro (15160759), Ashwin Adrian Kallor (7840853), Kevin Litchfield (8318559), Benjamin S. Simpson (8550819)   +5 more
core   +1 more source

Table_2_A Comprehensive Survey of Genomic Mutations in Breast Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.xlsx

, 2022
Neoantigens are mutated antigens specifically generated by cancer cells but absent in normal cells. With high specificity and immunogenicity, neoantigens are considered as an ideal target for immunotherapy.
Lijian Zhao (5734019), Hai-Xi Sun (9499079), Songming Liu (12267134), Si Zhou (669724)   +3 more
core   +1 more source

Obesity and Pathologic Response to Neoadjuvant Immunotherapy in Head and Neck Cancer: Preliminary Results From a Pilot Study

Head &Neck, EarlyView.
ABSTRACT Objective To evaluate associations between obesity and pathologic response to neoadjuvant immune checkpoint inhibitors (ICI) in patients with head and neck squamous cell carcinoma (HNSCC). Methods This was a retrospective cohort study conducted at a single tertiary academic center.
Angeline A. Truong, Laura Chen, Rex H. Lee, Xin Wu, Hyunseok Kang, Ivan H. El‐Sayed, Jonathan R. George, Chase M. Heaton, Ilya Likhterov, Michael Chow, Mary Jue Xu, Patrick K. Ha, Alain P. Algazi, Katherine C. Wai   +13 more
wiley   +1 more source

DataSheet_5_A Comprehensive Survey of Genomic Mutations in Breast Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.pdf

, 2022
Neoantigens are mutated antigens specifically generated by cancer cells but absent in normal cells. With high specificity and immunogenicity, neoantigens are considered as an ideal target for immunotherapy.
Lijian Zhao (5734019), Hai-Xi Sun (9499079), Songming Liu (12267134), Si Zhou (669724)   +3 more
core   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source