Results 161 to 170 of about 115,708 (268)

Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim, Na‐Young Seo, Seung‐Ki Kim, Jae‐Kyung Won, Yang Hoon Huh, Ji Yeoun Lee, Kea Joo Lee   +6 more
wiley   +1 more source

Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species. [PDF]

Sci Adv
Boulan B, Lacomme M, Benadjal A, Krueger M, Currie K, La Torre A, Chédotal A, Cayouette M.   +7 more
europepmc   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1. [PDF]

EMBO J
Bridlance C, Viguier S, Olivié N, Dupont E, Thobois D, Mathieu B, Jiang JX, López-Bendito G, Greter M, Becher B, Ginhoux F, Silvin A, Klingler E, Garel S, Thion MS.   +14 more
europepmc   +1 more source

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

A Novel Variant in the MYT1L Gene Shared by Three Individuals with Neuropsychiatric and Neurodevelopmental Manifestations in a Family. [PDF]

Indian J Psychol Med
Varghese NB, Karunakaran KB, Bhat K, Jain S, Purushottam M, Singhai K.   +5 more
europepmc   +1 more source

Migraine and Restless Legs Syndrome: A Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT Restless legs syndrome is a sensorimotor disorder of sleep/wake regulation that frequently coexists with migraine, affecting patients' quality of life. This study aimed to estimate the prevalence of restless legs syndrome in individuals with migraine and to explore the associated clinical, demographic and behavioural aspects.
Florindo d'Onofrio, Maria Cropano, Giada Panzino, Mariachiara Gaita, Giulio Cicarelli, Piero Barbanti, Gerardo Casucci, Simona Raimo, Antonio Costanzo   +8 more
wiley   +1 more source

Evolutionary neuroeconomic adaptations of fast-spiking neurons in the human neocortex. [PDF]

Front Synaptic Neurosci
Szegedi V, Douida A, Hutóczki G, Novák L, Lamsa K.   +4 more
europepmc   +1 more source

The Effect of Closed‐Loop Auditory Stimulation on Memory Consolidation and Sleep Physiology in an Ecological Setting

Journal of Sleep Research, EarlyView.
ABSTRACT Slow wave sleep plays a crucial role in overnight memory consolidation, with slow oscillations serving as a critical mechanism. Recent studies have identified closed‐loop auditory stimulation as an effective method to enhance slow oscillatory activity during slow wave sleep, thereby facilitating memory consolidation.
Angie Baldassarri, Damiana Bergamo, Federico Salfi, Domenico Corigliano, Michele Ferrara, Aurora D'Atri, Nicola Cellini   +6 more
wiley   +1 more source

Hexaraphane as a potential therapeutic strategy for tauopathies. [PDF]

Redox Biol
García-Yagüe ÁJ, Carnicero-Senabre D, Núñez Á, Cipriani R, Capetillo-Zarate E, Escoll M, Okunishi I, Rojo AI, Cuadrado A.   +8 more
europepmc   +1 more source