Results 141 to 150 of about 116,176 (291)

Dual computational systems in the development and evolution of mammalian brains. [PDF]

Sci Adv
Imam N, Kielo M, Trude BM, Finlay BL.
europepmc   +1 more source

Data‐driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology

Brain Pathology, EarlyView.
We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson   +10 more
wiley   +1 more source

How does the cerebellum contribute to cognitive functions? [PDF]

PLoS Biol
Diedrichsen J, McDougle SD.
europepmc   +1 more source

In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex

British Journal of Pharmacology, EarlyView.
Background and Purpose Maternal hypoxia is a recognised risk factor for neurodevelopmental disorders in offspring. Although rodent models of hypoxia have been reported, the detailed pathogenesis of maternal hypoxia‐induced neurodevelopmental disorders remains unclear.
Kentaro Tokudome, Masaaki Ueki, Takujiro Homma, Shinji Matsunaga, Saki Shimizu, Yukihiro Ohno, Shuhei Tomita   +6 more
wiley   +1 more source

Astrocyte heterogeneity in the neocortex: developmental origins, molecular diversity, and functional implications. [PDF]

Front Cell Dev Biol
Zhou J, Bocchi R.
europepmc   +1 more source

Region-specific ups and downs in mitochondrial numerical densities during Alzheimer's disease progression: A pilot study in human brains. [PDF]

J Alzheimers Dis
Balsliemke AL, Ahlemeyer B, Schmidl E, Acker T, Schänzer A, Baumgart-Vogt E.   +5 more
europepmc   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development. [PDF]

Nat Neurosci
Sonthalia S, Herb B, Adkins RS, Orvis J, Li G, Liao X, Yu Q, Blanco XM, Casella A, Liu J, Stein-O'Brien G, Caffo B, Hertzano R, Mahurkar A, Xu JC, Gillis J, Werner J, Ma S, Kim SK, Micali N, Sestan N, Rakic P, Santpere G, Ament SA, Colantuoni C.   +24 more
europepmc   +1 more source

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

Traumatic Brain Injury Induces Senescence in Brain Microvasculature. [PDF]

Biomolecules
Shreeya T, Hernádi ZR, Bali ZK, Bruszt N, Hernádi I, Fazekas B, Amrein K, Czeiter E, Fazakas C, Wilhelm I, Krizbai IA, Farkas AE.   +11 more
europepmc   +1 more source