Results 131 to 140 of about 116,176 (291)

Posttranscriptional Control of Neural Progenitors Temporal Dynamics During Neocortical Development by Syncrip

Advanced Science
The development of the mammalian neocortex is precisely regulated by temporal gene expression, yet the temporal regulatory mechanisms of cortical neurogenesis, particularly how radial glial cells (RGCs) sequentially generate deep to superficial neurons ...
Jiarui Wu, Haoyang Yu, Xinyi Dou, Bin Yin, Lin Hou, Yuanchao Xue, Boqin Qiang, Pengcheng Shu, Xiaozhong Peng   +8 more
doaj   +1 more source

A Hybrid RF Coil for Whole‐Brain Imaging in Non‐Human Primates at 7 T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Ultra‐high field MRI (≥ 7 T) offers unprecedented potential for mapping non‐human primate (NHP) brain function. However, complex electromagnetic systems are required to meet the challenges of UHF imaging and the mechanical demands of awake NHP studies.
Elias Djaballah, Éric Giacomini, Paul‐François Gapais, Michel Luong, Alexis Amadon, Qi Zhu   +5 more
wiley   +1 more source

Preclinical 1H MRS Study of a Porcine Model Shows Evidence and Mechanisms for Acute Neuronal Injury in Neonatal Cardiopulmonary Bypass (CPB) Surgery

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Congenital heart disease affects 1% of US births, with some infants requiring cardiothoracic surgery under cardiopulmonary bypass (CPB). Optimal surgical parameters to minimize neuronal injury are unknown. We used serial 1H MRS in a neonatal CPB porcine model to assess acute neuronal damage and associated injury mechanisms.
Aaron Omon, Meng Gu, Ralph Hurd, Kirk Riemer, Frank Hanley, Daniel Spielman   +5 more
wiley   +1 more source

Tradeoffs between brain and digestive tissues across elevations in Typhlomys daloushanensis: evidence for sexual dimorphism

Wildlife Biology, EarlyView.
To cope with highly stochastic and/or heterogeneous environmental conditions, animals must balance energy resource allocation across physiological processes. The digestive tract and brain exhibit structural variations under strong developmental and selective pressures that vary across environmental gradients both between and within species.
Yimei Yan, Bangqing Chen, Jifa Cui, Chris Newman, Boyu Lei, Nan Wu, Jinwei Wu, Jin Zhao, Christina D. Buesching, Youbing Zhou   +9 more
wiley   +1 more source

Neocortex [PDF]

, 2011
openaire   +2 more sources

Volumetric Comparison of Overall Brain and Neuropil Size Between Social and Non‐social Spiders: Exploring the Social Brain Hypothesis

Integrative Zoology, EarlyView.
Brain size may be influenced by the cognitive demands of sociality (social brain hypothesis). We used microCT to compare CNS and brain volumes in social versus solitary huntsman and crab spiders. Social huntsman spiders had larger arcuate and mushroom bodies, while social crab spiders had larger visual neuropils.
Vanessa Penna‐Gonçalves, Donald James Mclean, Nikolas J. Willmott, Michael B. J. Kelly, Jay R. Black, Elizabeth C. Lowe, Marie E. Herberstein   +6 more
wiley   +1 more source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, EarlyView.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source