Results 111 to 120 of about 68,495 (293)
Epilepsia, EarlyView.Abstract Objective Quantitative assessment of extent of tissue resection following epilepsy surgery requires accurate delineation of the resection cavity on postoperative magnetic resonance imaging (MRI). Current methods for resection cavity masking are time‐consuming and labor‐intensive, and existing automated approaches exhibit variable segmentation ...
Jieun Seo +91 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective In temporal lobe epilepsy (TLE), patients often present with neurobehavioral comorbidities encompassing affective and cognitive difficulties. Whereas the latter have been related to atypical connectivity of mesiotemporal and frontotemporal circuits, the brain basis of affective symptoms remains incompletely understood.
Fatemeh Fadaie +4 more
wiley +1 more source
Scn1a‐mediated developmental regulation of prefrontal cortex plasticity and cognition
Epilepsia, EarlyView.Abstract Objective The voltage‐gated sodium channel Nav1.1, encoded by Scn1a, is essential for γ‐aminobutyric acid (GABA)ergic function, and its alteration is associated with neurological disorders such as Dravet syndrome and Alzheimer's disease. We previously demonstrated that local Nav1.1 dysfunction in the medial prefrontal cortex (mPFC) during ...
Maurizio S. Riga +5 more
wiley +1 more source
Kv3.1 activation suppresses provoked and spontaneous seizures in a mouse Dravet syndrome model
Epilepsia, EarlyView.Abstract Objective γ‐Aminobutyric acidergic (GABAergic) parvalbumin‐positive (PV+) interneurons are critical for maintaining cortical inhibitory tone, with their dysfunction predictably leading to epilepsy. Rapid PV+ interneuron firing is essential for their normal function and is maintained in part by potassium voltage‐gated channels.
Sheryl Anne D. Vermudez +11 more
wiley +1 more source
Neocortex development and evolution.
, 2013 A) A coronal plane of section through an embryo. One hemisphere is shown diagrammatically. The neocortex develops from the dorsal telencephalon. At E14.5 progenitor cells from the ventricular zone (VZ) are producing intermediate progenitor cells that ...
Aaron M. Wenger (145784) +7 more
core +1 more source
Limited sex‐specific structural alterations across common epilepsies: A worldwide ENIGMA study
Epilepsia, EarlyView.Abstract Objective Epilepsy is characterized by widespread cortical and subcortical structural alterations beyond the epileptic zone. Importantly, the clinical manifestation of epilepsy, including seizure types, psychiatric comorbidities, and treatment responses, has been shown to differ between sexes. However, sex differences in structural alterations
Huantao Wen +68 more
wiley +1 more source
Cell proliferation without neurogenesis in adult primate neocortex
, 2001 A recent assertion that new neurons are continually added to the neocortex of adult macaque monkeys has profound implications for understanding the cel-lular mechanisms of higher cognitive functions.
David R. Kornack, Pasko Rakic
core
Transcriptomic analysis reveals distinct expression patterns in focal cortical dysplasia
Epilepsia, EarlyView.Abstract Objective Focal cortical dysplasia (FCD) is a common cause of drug‐resistant epilepsy in children and adults and exhibits substantial clinical and histopathological heterogeneity. However, morphological classification alone does not fully explain variability in epileptogenicity, disease severity, or treatment response.
Shivani Sonawane +20 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective To clinically validate the contribution of a custom‐built EEG wearable device (waEEG) compared to a full 10–20 electrode array ambulatory EEG (aEEG) for screening epilepsy cases in patients with suspected temporal lobe epilepsy (TLE) but negative routine EEGs. Methods Patients (aged 16–91 years) with clinically suspected TLE who were
Daniel Filipe Borges +4 more
wiley +1 more source
Changes in cortical interneuron migration contribute to the evolution of the neocortex
, 2011 The establishment of the mammalian neocortex is often explained phylogenetically by an evolutionary change in the pallial neuronal progenitors of excitatory projection neurons.
Erika Sasaki +3 more
core +1 more source