Results 91 to 100 of about 2,140 (214)

Postoperative reduction of anti‐seizure medication is associated with cognitive improvement in seizure‐free patients after anterior temporal lobectomy

Epilepsia, EarlyView.
Abstract Objective To determine whether postoperative reduction of anti‐seizure medication (ASM) burden is associated with cognitive improvement after anterior temporal lobectomy (ATL) in seizure‐free patients. Methods We retrospectively analyzed data for adult patients with drug‐resistant temporal lobe epilepsy who underwent unilateral ATL between ...
Kazushi Ukishiro, Shin‐ichiro Osawa, Maimi Ogawa, Makoto Ishida, Takafumi Kubota, Kazutoshi Konomatsu, Hidenori Endo, Kazutaka Jin   +7 more
wiley   +1 more source

Translocator protein positron emission tomography as a biomarker for posttraumatic epilepsy and behavioral comorbidities following traumatic brain injury

Epilepsia, EarlyView.
Abstract Objective Traumatic brain injury (TBI) induces widespread and persistent neuroinflammation, which is increasingly recognized as a key contributor to chronic sequelae including posttraumatic epilepsy (PTE), cognitive deficits, and neuropsychiatric disturbances. However, reliable biomarkers for identifying individuals at risk for these long‐term
Mohit Javalgekar, Peravina Thergarajan, Juliana Silva, Emma Braine, Robert Brkljača, Pablo M. Casillas‐Espinosa, Stefanie Dedeurwaerdere, Mohammad Haskali, Usama Kamil, Terence J. O'Brien, Nigel C. Jones, David K. Wright, Bianca Jupp, Lucy Vivash, Idrish Ali   +14 more
wiley   +1 more source

Spike detection in the wild: Screening of suspected temporal lobe epilepsy cases using a tailored 2‐channel wearable EEG

Epilepsia Open, EarlyView.
Abstract Objective To clinically validate the contribution of a custom‐built EEG wearable device (waEEG) compared to a full 10–20 electrode array ambulatory EEG (aEEG) for screening epilepsy cases in patients with suspected temporal lobe epilepsy (TLE) but negative routine EEGs. Methods Patients (aged 16–91 years) with clinically suspected TLE who were
Daniel Filipe Borges, Joana Isabel Soares, Daniela Dias, Helena Cordeiro, Alberto Leal   +4 more
wiley   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

An Introduction to Predictive Processing Models of Perception and Decision‐Making

Topics in Cognitive Science, EarlyView., 2023
Abstract The predictive processing framework includes a broad set of ideas, which might be articulated and developed in a variety of ways, concerning how the brain may leverage predictive models when implementing perception, cognition, decision‐making, and motor control.
Mark Sprevak, Ryan Smith
wiley   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Influence of age on nicotinic cholinergic regulation of blood flow in rat’s olfactory bulb and neocortex

Journal of Physiological Sciences
The olfactory bulb receives cholinergic basal forebrain inputs as does the neocortex. With a focus on nicotinic acetylcholine receptors (nAChRs), this review article provides an overview and discussion of the following findings: (1) the nAChRs-mediated ...
Sae Uchida, Fusako Kagitani
doaj   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

A developmental approach to homology and brain evolution Un enfoque embriológico a la homología y la evolución cerebral

Revista Chilena de Historia Natural, 2010
Although homology is central to evolutionary interpretations, establishing it has become a highly disputed issue in some instances. Here I argüe for a developmental understanding of evolution, where modifications of the developmental programs are a key ...
FRANCISCO ABOITIZ
doaj