Results 61 to 70 of about 68,495 (293)
The columnar organization of the neocortex [PDF]
Brain, 1997 The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example. The classical cytoarchitectural areas of the neocortex are composed of smaller units, local neural circuits repeated iteratively within each area.
openaire +2 more sources
How neural stem cells contribute to neocortex development.
, 2021 The mammalian neocortex is the seat of higher cognitive functions, such as thinking and language in human. A hallmark of the neocortex are the cortical neurons, which are generated from divisions of neural progenitor cells (NPCs) during development, and ...
Wilsch-Bräuninger, M. +5 more
core +1 more source
A Reconfigurable Memristive Spiking Neuron Enabling Advanced Neuromorphic Computing
Advanced Science, EarlyView.Pek Jun Tiw and co‐workers develop a reconfigurable memristive neuron that can exhibit four spiking behaviors with freely tunable spike train parameters. The neuron supports multiplexed spike encoding of multiple pieces of information. It also supports advanced neural network strategies, such as neural heterogeneity and dynamic mode switching ...
Pek Jun Tiw +6 more
wiley +1 more source
Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia
Advanced Science, EarlyView.The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian +12 more
wiley +1 more source
Frontiers in Neural Circuits, 2018 Neuromodulators, such as acetylcholine (ACh), control information processing in neural microcircuits by regulating neuronal and synaptic physiology. Computational models and simulations enable predictions on the potential role of ACh in reconfiguring ...
Srikanth Ramaswamy +2 more
doaj +1 more source
Neocortex neurogenesis and maturation in the African greater cane rat
Neural Development, 2023 Background Neocortex development has been extensively studied in altricial rodents such as mouse and rat. Identification of alternative animal models along the “altricial-precocial” spectrum in order to better model and understand neocortex development ...
Oluwaseun Mustapha +3 more
doaj +1 more source
TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains
Advanced Science, EarlyView.Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang +14 more
wiley +1 more source
Schema-Dependent Gene Activation and Memory Encoding in Neocortex
, 2011 New hippocampal-dependent learning is in parallel consolidated with existing memories in the neocortex.
Haruhiko Bito +15 more
core +1 more source
Contextual modulation in mammalian neocortex is asymmetric [PDF]
, 2020 Neural systems are composed of many local processors that generate an output given their many inputs as specified by a transfer function. This paper studies a transfer function that is fundamentally asymmetric and builds on multi-site intracellular ...
Kay, Jim W. +5 more
core +1 more source
Advanced Science, EarlyView.Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin +7 more
wiley +1 more source