Results 191 to 200 of about 82,892 (269)

Copper Overload Affects α‐Synuclein Clearance Mechanisms in a Parkinson's Disease In Vitro Model

Advanced Biology, Volume 10, Issue 5, May 2026.
This study reveals that copper overload disrupts neuronal protein clearance, leading to the accumulation of α‐synuclein and its phosphorylated form (p‐S129). By blocking autophagy and impairing the ubiquitin–proteasome system, copper promotes toxic aggregation in dopaminergic cells.
Debora Musarò, Marina Damato, Chiara Coppola, Marco Greco, Michele Maffia   +4 more
wiley   +1 more source

Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1. [PDF]

EMBO J
Bridlance C, Viguier S, Olivié N, Dupont E, Thobois D, Mathieu B, Jiang JX, López-Bendito G, Greter M, Becher B, Ginhoux F, Silvin A, Klingler E, Garel S, Thion MS.   +14 more
europepmc   +1 more source

Association of plasma biomarkers with amyloid and tau PET in pre‐dementia stages

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Measuring plasma biomarkers effectively assesses early‐stage Alzheimer's disease. METHODS Subjects were categorized as cognitively unimpaired (CU) (n = 66), CU with subjective cognitive decline (SCD) (n = 100), and mild cognitive impairment (MCI) (n = 25).
Allal Boutajangout, Arjun V. Masurkar, Ricardo Osorio, Ludovic Debure, Mobeena Ghuman, Wajiha Ahmed, Alok Vedvyas, Elizabeth Pirraglia, Jon Links, Louisa Bokacheva, Brianna Vega, Mark A. Bernard, Karyn Marsh, Omonigho M Bubu, Yongzhao Shao, Joshua Chodosh, Henry Rusinek, Thomas Wisniewski   +17 more
wiley   +1 more source

Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex. [PDF]

EMBO J
Shen D, Wang XY, Liu RH, Deng HH, Tong SY, Chen JY, Zhai ZY, Li YX, Lin YN, Yang FW, Wang CX, Liu LY, Zhu Y, Yu YC.   +13 more
europepmc   +1 more source

The Clinical Spectrum and Neurodevelopmental Pathogenesis of KPTN‐Related Disorder in a Mouse Model

Annals of Neurology, Volume 99, Issue 5, Page 1287-1302, May 2026.
Objective Pathogenic variants in Kaptin (KPTN) cause KPTN‐related disorder (KRD). KPTN modulates mTOR signaling activation within the KICSTOR complex in response to cellular amino acid levels. We define the clinical spectrum and investigate the developmental pathogenesis of KRD.
Lettie E. Rawlins, Philip H. Iffland II, John Page, Rebecca Z. Flessner, Soad M. Elziny, Irina Sbornova, Janice K. Babus, Sophie R. Bruckmeier, Ria Parikh, Merel Verhoeven, James Fasham, Joseph S. Leslie, Richard Caswell, Nishanka Ubeyratna, Olivia Wenger, Ethan M. Scott, John Schreiber, Steffen Syrbe, Annick Klabunde‐Cherwon, Martina Owens, Andrew H. Crosby, Emma L. Baple, Peter B. Crino, the KPTN Consortium, Andrea Seeley, Heather Rocha, Sabine Rudnick, Ulrich Schaatz, Tobias Haack, Eva Schwaibold, Caleb Bupp, Klaas Wierenga, John Schreiber, Thorkild Terkelsen, Sarina Kant, J. C. Herkert, Michael Wright, Boris Keren, Solveig Heide, Pamela Jackson, Pradeep Vasudevan, Helen Stewart, Perrine Charles, Andreas Hahn, Saskia Biskup, Inger‐Lise Mero, Martin Heier, Conny van Ravenswaaij‐Arts, Esther Nibbeling, Stephanie Efthymiou, Erum Afzal, Ian Ellis, Raza Maroofian, Almundher Al‐Maawali, David Coman, Anthony Morosini, Sajjad Biglari, Pooneh Nikuei, Saadet Mercimek‐Andrews, Prab Prabhakar, Raymond Louie, Kameryn Butler, Olivia Wenger, Ethan M. Scott, Andrea Seeley, Heather Rocha, Amber Begtrup, Sabine Rudnik, Ulrich Schatz, Tobias Haack, Eva Schwaibold, Caleb Bupp, Klaas Wierenga, John Schreiber, Thorkild Terkelsen, Sarina Kant, J. C. Herkert, Michael Wright, Boris Keren, Solveig Heide, Pamela Jackson, Pradeep Vasudevan, Helen Stewart, Perrine Charles, Andreas Hahn, Saskia Biskup, Inger‐Lise Mero, Martin Heier, Marijn Stokman, Conny van Ravenswaaij‐Arts, Esther Nibbeling, Stephanie Efthymiou, Erum Afzal, Kristina Zhelcheska, Henry Houlden, Ian Ellis, Reza Maroofian, Gholamreza Shariati, Hamid Galehdari, Almundher Al‐Maawali, Adila Al‐Kindi, Andrew Y. Shuen, Victoria Siu, Annick Klabunde‐Cherwon, Steffen Syrbe   +104 more
wiley   +1 more source

Selective vulnerability of GABAergic neurons in chronic migraine. [PDF]

J Headache Pain
Hossain KH, Chuong T, Abad E, Lin J, Xia C, Li M, Chen Y, Arakaki X, Vasudevan A.   +8 more
europepmc   +1 more source

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, Volume 99, Issue 5, Page 1343-1353, May 2026.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source

Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species. [PDF]

Sci Adv
Boulan B, Lacomme M, Benadjal A, Krueger M, Currie K, La Torre A, Chédotal A, Cayouette M.   +7 more
europepmc   +1 more source

Molecular Characterization of Neurological Abnormalities in Nidogen-deficient Mice [PDF]

, 2008
Ho, Sai Pong
core  

Protein‐Template Gold Nanoclusters Induce Differentiation and Modify the Functional Properties of Primary Astrocytes

Advanced NanoBiomed Research, Volume 6, Issue 5, May 2026.
The incubation of primary astrocytes with fAuNCs‐BSA induces: (A) long‐term effects including fAuNCs‐BSA internalization, red cell fluorescence, differentiation, upregulation of Ca2+ signaling, Cl‐current, and cell volume regulation. B) Short‐term (200 ms) stimulation with UV LED light increases in Ca2+ signaling and inhibition of K+ current. Astrocyte
Roberta Fabbri, Karima Jeneh Perry, Emanuela Saracino, Chiara Lazzarini, Anna Mariano, Diletta Spennato, Maria Grazia Mola, Maria Grazia Raucci, Alessandro Kovtun, Marianna Barbalinardo, Giorgia Conte, Denis Gentili, Marco Caprini, Vincenzo Palermo, Roberto Zamboni, Luigi Ambrosio, Wolfgang Losert, Andrea Candini, Grazia Paola Nicchia, Raj K. Gupta, Valentina Benfenati, Shashi P. Karna   +21 more
wiley   +1 more source