Results 141 to 150 of about 24,656 (260)

The internal larval anatomy of two rodent bot fly species: Cuterebra fontinella (Diptera: Oestridae) and Cuterebra americana. [PDF]

J Med Entomol
Martín-Vega D, Bailey EM, Lanzetti A, Hall MJR.   +3 more
europepmc   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Mineral Stabilization of Soil Organic Sulfur at the Continental Scale. [PDF]

Glob Chang Biol
Zhang Z, Cotrufo MF, Turner BL, Mao HR, Liang C, Shakouri M, Zhu M.   +6 more
europepmc   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Governing Ethical Tensions in Youth Digital Mental Health Research. [PDF]

JMIR Ment Health
Ørjasæter KB, Rennick-Egglestone S, Børresen KØ, Moe CF, Leiler A, Sigurdardóttir HD, Colado VMP, Vogelsang M, Nambazira T, Trovåg J, Valderaune V, Skjesol I, Ng F, Ness O, Slade M.   +14 more
europepmc   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Temperature and Resource Supply Drive Continental Variation in Size Structure of Freshwater Food Webs. [PDF]

Ecol Lett
Gjoni V, Pomeranz JPF, Junker JR, Wesner JS.   +3 more
europepmc   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Bridging the Energy Balance Gap in Eddy-Covariance Measurements: Insights From Standardized Network Data. [PDF]

Glob Chang Biol
Nicolini G, Durden D, Di Fiore L, Florian C, Sabbatini S, Gielen B, Iserbyt A, Loubet B, Mammarella I, Mariotti A, Op de Beeck M, Slemmons C, Trotta C, Young A, Chabbi A, Feigenwinter I, Heinesch B, Kowalska N, Mauder M, Šigut L, van der Molen M, Bastos Campos F, Berveiller D, Brümmer C, Cuntz M, Domec JC, Dumont B, Fares S, Gianelle D, Jensen R, Kalalian C, Kljun N, Lange H, Limousin JM, Lundin E, Manco A, Montagnani L, Nemitz E, Peichl M, Rinne E, Roland M, Schmidt M, Simioni G, Thomas A, Vincke C, Papale D.   +45 more
europepmc   +1 more source

Disabling COMPASS Promoter Licensing Shifts HDAC‐Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery

Advanced Science, EarlyView.
Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song, Hui Yu, Jianping Jiang, Zhihui Jiang, Zhongshi Hong, Xu Zhang, Luchuan Chen, Shenghong Wei, Yi Wang   +8 more
wiley   +1 more source