Results 161 to 170 of about 23,878 (259)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović   +11 more
wiley   +1 more source

Plasmakristall‐4 Experiment: 10 Years of Operation in Orbit

open access: yesContributions to Plasma Physics, EarlyView.
ABSTRACT Plasmakristall‐4 (PK‐4) is a microgravity complex plasma laboratory operated for 10 years on board the International Space Station. Its main purpose is the particle‐resolved investigation of generic condensed matter phenomena using strongly coupled suspensions of microparticles immersed in low‐pressure gas‐discharge plasmas.
M. Pustylnik   +3 more
wiley   +1 more source

Heat Load Mitigation Studies in the W7‐X Stellarator Experiment

open access: yesContributions to Plasma Physics, EarlyView.
ABSTRACT During the experiments at the stellarator Wendelstein 7‐X (W7‐X) with fully water‐cooled plasma‐facing components (PFC), including carbon‐fiber composite (CFC) divertor targets with a thermal load capability of 10 MW/m2, high performance was achieved.
Dirk Naujoks   +11 more
wiley   +1 more source

Energy-levels of Neon

open access: yesProceedings of the Physico-Mathematical Society of Japan. 3rd Series, 1939
ARAKI, Gentaro, YAMAMOTO, Yosizo
openaire   +2 more sources

First SOLPS‐ITER Simulation Study of Japanese DEMO on Leakage of Seeded Ar Impurity

open access: yesContributions to Plasma Physics, EarlyView.
ABSTRACT For JA DEMO, one of the grand challenges is efficiently handling the extreme power loads onto plasma‐facing components, particularly the divertor targets. Impurity seeding is an essential strategy for increasing the radiation losses and thereby reducing the heat load on the targets.
Hang Si   +6 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

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