Results 61 to 70 of about 57,085 (307)

Disrupted brain connectivity in children treated with therapeutic hypothermia for neonatal encephalopathy

NeuroImage: Clinical, 2021
Therapeutic hypothermia following neonatal encephalopathy due to birth asphyxia reduces death and cerebral palsy. However, school-age children without cerebral palsy treated with therapeutic hypothermia for neonatal encephalopathy still have reduced ...
Arthur P.C. Spencer, Jonathan C.W. Brooks, Naoki Masuda, Hollie Byrne, Richard Lee-Kelland, Sally Jary, Marianne Thoresen, James Tonks, Marc Goodfellow, Frances M. Cowan, Ela Chakkarapani   +10 more
doaj   +1 more source

Phenotypic Diversity and Outcomes in Pediatric NMDA Receptor Encephalitis: A 15‐Year Retrospective Study from the Largest Children's Hospital in the United States

Advanced Science, EarlyView.
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss, Timothy Erickson, Yike Jiang, Varun Kannan, Jonathan M. Yarimi, Kristen S. Fisher, Nikita Shukla, Tim Lotze, Eyal Muscal, Kristy O. Murray   +9 more
wiley   +1 more source

Therapeutic Hypothermia for Neonatal Encephalopathy [PDF]

Current Treatment Options in Neurology, 2012
Neonatal Hypoxic-ischemic encephalopathy in full term infants has been associated with a high risk for morbidity and mortality. The patho-physiology of brain injury following hypoxia-ischemia, noted in preclinical models, is a cascade of events resulting from excitotoxic and oxidative injury culminating in cell death.
openaire   +3 more sources

Placental pathology and neonatal encephalopathy

International Journal of Gynecology & Obstetrics, 2022
AbstractNeonatal encephalopathy (NE) is an important cause of neonatal morbidity and mortality worldwide; however, there remain gaps in our knowledge about its pathogenesis. The placenta has been implicated in the pathogenesis of this disease but conclusive evidence related to the placental factors that influence it is sparse.
Aine Fox, Emma Doyle, Michael Geary, Breda Hayes   +3 more
openaire   +2 more sources

Ultrasonographic Evaluation of the Neonatal Brain in Cases of Birth Asphyxia [PDF]

International Journal of Anatomy Radiology and Surgery, 2016
Introduction: Hypoxic ischemic encephalopathy (HIE) is a common condition in newborns as a result of birth asphyxia. Affected neonates display a number of clinical features by which the condition may be suspected.
Susmita Giri, Tapan Kumar Jana, Arunabha Tapadar   +2 more
doaj   +1 more source

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

Barrier mechanisms in neonatal stroke. [PDF]

, 2014
Clinical data continue to reveal that the incidence of perinatal stroke is high, similar to that in the elderly. Perinatal stroke leads to significant morbidity and severe long-term neurological and cognitive deficits, including cerebral palsy ...
Chip, Sophorn, Kratzer, Ingrid, Vexler, Zinaida S   +2 more
core   +2 more sources

Diagnostic Odyssey of Atypical Long‐Chain 3‐Hydroxyacyl‐CoA Dehydrogenase Deficiency (LCHADD) Explained by Three Allelic Products From Two Pathogenic Variants

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency (LCHADD) is an autosomal recessive mitochondrial defect of long‐chain fatty acid β‐oxidation, caused by biallelic pathogenic variants in HADHA or HADHB. We report a 22‐year‐old male with an atypically mild presentation of LCHADD who was referred to the Undiagnosed Diseases Network (UDN ...
Yutaka Furuta, Lynette C. Rives, T. Andrew Burrow, Thomas A. Cassini, Rory J. Tinker, Amy K. Robertson, Kimberly M. Ezell, Rizwan Hamid, Joy D. Cogan, John A. Phillips III   +9 more
wiley   +1 more source

Cerebral function monitoring in term or near term neonates at MDH : preliminary experience and proposal of a guideline [PDF]

, 2012
Introduction: Cerebral function monitoring (CFM) is a simplified EEG device that is used to monitor cerebral function at the cot-side. Various studies have shown its value in detecting neonatal encephalopathy and electrographic seizures, prognostication ...
Attard, Stephen, Soler, Doriette, Soler, Paul   +2 more
core  

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. [PDF]

, 2011
Permanent damage to white matter tracts, comprising axons and myelinating oligodendrocytes, is an important component of brain injuries of the newborn that cause cerebral palsy and cognitive disabilities, as well as multiple sclerosis in adults. However,
Baranzini, Sergio E, Bruce, Charlotte C, Fancy, Stephen PJ, Franklin, Robin JM, Harrington, Emily P, Huang, Eric J, Nusse, Roel, Otero, Jose J, Rowitch, David H, Silbereis, John C, Yuen, Tracy J, Zhao, Chao   +11 more
core   +3 more sources