Results 41 to 50 of about 34,890 (296)

Hypothermia for encephalopathy in low and middle-income countries (HELIX): study protocol for a randomised controlled trial

Trials, 2017
Background Therapeutic hypothermia reduces death and disability after moderate or severe neonatal encephalopathy in high-income countries and is used as standard therapy in these settings.
Sudhin Thayyil, Vania Oliveira, Peter J. Lally, Ravi Swamy, Paul Bassett, Mani Chandrasekaran, Jayashree Mondkar, Sundaram Mangalabharathi, Naveen Benkappa, Arasar Seeralar, Mohammod Shahidullah, Paolo Montaldo, Jethro Herberg, Swati Manerkar, Kumutha Kumaraswami, Chinnathambi Kamalaratnam, Vinayagam Prakash, Rema Chandramohan, Prathik Bandya, Mohammod Abdul Mannan, Ranmali Rodrigo, Mohandas Nair, Siddarth Ramji, Seetha Shankaran, for the HELIX Trial group   +24 more
doaj   +1 more source

Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy

Neural Regeneration Research, 2017
Although hypothermia therapy is effective to treat neonatal hypoxic-ischemic encephalopathy, many neonatal patients die or suffer from severe neurological dysfunction. Erythropoietin is considered one of the most promising neuroprotective agents.
Hong-yan Lv, Su-jing Wu, Qiu-li Wang, Li-hong Yang, Peng-shun Ren, Bao-jun Qiao, Zhi-ying Wang, Jia-hong Li, Xiu-ling Gu, Lian-xiang Li   +9 more
doaj   +1 more source

Prognostic Neurobiomarkers in Neonatal Encephalopathy

Developmental Neuroscience, 2022
Therapeutic hypothermia (TH) is now a standard treatment for infants with moderate-to-severe neonatal encephalopathy (NE), and improves brain damage on neuroimaging and neurodevelopmental outcomes. Critically, for effective neuroprotection, hypothermia should be started within 6 h from birth. There is compelling evidence to suggest that a proportion of
Guido Wassink, Steven Harrison, Simerdeep Dhillon, Laura Bennet, Alistair Jan Gunn   +4 more
openaire   +2 more sources

Transplantation of human placental chorionic plate-derived mesenchymal stem cells for repair of neurological damage in neonatal hypoxic-ischemic encephalopathy

Neural Regeneration Research
[INLINE:1] Neonatal hypoxic-ischemic encephalopathy is often associated with permanent cerebral palsy, neurosensory impairments, and cognitive deficits, and there is no effective treatment for complications related to hypoxic-ischemic encephalopathy. The
Lulu Xue, Ruolan Du, Ning Bi, Qiuxia Xiao, Yifei Sun, Ruize Niu, Yaxin Tan, Li Chen, Jia Liu, Tinghua Wang, Liulin Xiong   +10 more
doaj   +1 more source

Intrapartum factors associated with neonatal hypoxic ischemic encephalopathy: a case-controlled study

BMC Pregnancy and Childbirth, 2017
Background Neonatal encephalopathy (NE) affects 2–4/1000 live births with outcomes ranging from negligible neurological deficits to severe neuromuscular dysfunction, cerebral palsy and death.
Vanessa E. Torbenson, Mary Catherine Tolcher, Kate M. Nesbitt, Christopher E. Colby, Sherif A. EL-Nashar, Bobbie S. Gostout, Amy L. Weaver, Michaela E. Mc Gree, Abimbola O. Famuyide   +8 more
doaj   +1 more source

Correlation of Thompson Score in Predicting Early Outcome of Newborn with Birth Asphyxia

Journal of Nepal Health Research Council, 2020
Background: Birth asphyxia is one of the important causes of neonatal morbidity and mortality, accounting up to 30% of neonatal death in Nepal. It is also an important cause of long term neurological disability and impairment.
Sabina Shrestha, Sangita Puree Dhungana, Sujit Shrestha, Gentle Sunder Shrestha   +3 more
doaj   +1 more source

Neonatal encephalopathies

BMJ, 1998
Papers pp 1549,1544 Neonatal encephalopathy is a significant problem. The United States collaborative perinatal project studied 39 000 infants born with birth weights greater than 2500 g and found that 70% of the infants who showed early neonatal depression and encephalopathy died or were disabled.1 For many years it was accepted that fetal asphyxia ...
Edwards, A. D., Nelson, K. B.
openaire   +3 more sources

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Rocha-Ferreira, E, Eridan Rocha-Ferreira, Eridan eRocha-Ferreira, Mariya eHristova, Hristova, M, Mariya Hristova   +5 more
core   +1 more source

Changing clinical characteristics of infants treated for hypoxic ischaemic encephalopathy in England, Wales and Scotland: a population-based study using the National Neonatal Research Database

, 2021
Background Therapeutic hypothermia is standard of care for babies with moderate/severe hypoxic-ischaemic encephalopathy and is increasingly used for mild encephalopathy.
Gale, Christopher, Sharkey, Don, Jeyakumaran, Dusha, Battersby, Cheryl, Ojha, Shalini, Longford, Nicholas, Gale, Chris, Modi, Neena, Modi, N, Hage, lory, Dorling, Jon, Longford, Nick   +11 more
core   +1 more source