Results 101 to 110 of about 1,686,776 (208)

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Portuguese Consensus Guidelines for the Diagnosis and Treatment of Myasthenia Gravis

Acta Médica Portuguesa
Myasthenia gravis is an autoimmune disease that affects the neuromuscular junction, mainly through the action of pathogenic antibodies such as those directed against the nicotinic acetylcholine receptor or, more infrequently, against the muscle specific
Simão Cruz, Anabela Matos, Luís Braz, Catarina Falcão Campos, João Cerqueira, Luísa Medeiros, Ernestina Santos, Luís Santos, Andreia Veiga   +8 more
doaj   +1 more source

Crystal structure of the complex of rat neonatal Fc receptor with Fc

, 1994
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the bloodstream of the newborn. FcRn is structurally similar to class I major histocompatibility complex (MHC) molecules, despite differences in the ligands they bind (the Fc ...
Bjorkman, Pamela J., Burmeister, Wilhelm P., Huber, Andrew H.   +2 more
core  

Determinants of preterm pre‐eclampsia following low‐dose aspirin prophylaxis: evidence from stepped‐wedge cluster randomized trial in Asia

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objectives To identify potential risk factors – among maternal factors, pre‐eclampsia (PE)‐specific biomarkers and estimated risks derived from the first‐trimester Fetal Medicine Foundation (FMF) triple test – that are associated with the subsequent development of preterm PE, and to evaluate predictors of any‐onset PE using time‐to‐event ...
J. Lin, L. Nguyen‐Hoang, L. T. Dinh, R. K. Pooh, A. Ohkuchi, M. Zheng, Y. Wu, A. Kusuma, T. Wataganara, M. Choolani, M. Kaneko, S. Luewan, T.‐Y. Chang, N. Chaiyasit, T. Nanthakomon, H. Liu, S. W. Shaw, L. C. Poon, FORECAST collaborators, I. S. Wong, J. S. Y. Wong, Y. Chen, J. Liu, X. Wang, S. Moungmaithong, X. Lu, L. Wong, F. Liu, A. W. T. Tse, H. H. Y. Leung, N. M. W. Lee, S. L. Lau, I. Y. M. Wah, D. S. Sahota, M. K. C. Chong, D.‐A. Nguyen, A. Shiozaki, Y. Hu, R. Ma, B. Li, Y. M. Jiang, A. Gosavi, A. Sekizawa, W. C. Leung, Z. A. Mahdy, A. Aguilar, O. Shimokawa   +46 more
wiley   +1 more source

Association Between Proteinuria and Pregnancy Outcomes in Women With Preterm Pre‐Eclampsia Undergoing Expectant Management: Secondary Analysis of Two Randomised Trials

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Evaluate whether proteinuria levels, in women undergoing expectant management for pre‐eclampsia, are associated with pregnancy latency and adverse outcomes. Design Secondary analysis of data from two randomised trials. Setting Tygerberg Hospital, Cape Town, South Africa.
Amy van Rooyen, Lina Bergman, Henrik Imberg, Denise Sproul, Susan P. Walker, Stephen Tong, Catherine A. Cluver   +6 more
wiley   +1 more source

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Registered trials on novel therapies for myasthenia gravis: a cross-sectional study on ClinicalTrials.gov

Scientific Reports
Novel biologics in MG therapy research is on the rise. This research aimed to investigate the characteristics of registered trials on novel therapies for myasthenia gravis on ClinicalTrials.gov.
Xingyue Li, Jinxin Chen, Youtao Wang, Siwei Zheng, Kun Wan, Xiaodong Liu   +5 more
doaj   +1 more source

National Neonatal Transport Programme: clinical report 2004-2008

, 2009
As is internationally recognised, the success of the centralisation of resources and expertise In the area of neonatology Is dependent on a reliable and effective transport service, The NNTP Is achieving this by the provision of: A comprehensive ...
Bowden, Ann
core  

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source