Results 91 to 100 of about 1,686,776 (208)

Effectiveness and safety of efgartigimod in patients with anti‐NMDAR or anti‐LGI1 encephalitis and its 18F‐DPA714 PET imaging evaluation: A multicenter, single‐arm, prospective, observational real‐world study

Neuroprotection, EarlyView.
Abstract Background Efgartigimod disrupts the recycling of pathogenic IgG autoantibodies and may represent a candidate therapy for autoimmune encephalitis. This real‐world study evaluated the clinical efficacy, safety, and impact of efgartigimod on brain inflammation.
Huanyu Meng, Siqi Tu, Yifan Zhou, Ruinan Shen, Xiaoyu Chen, Zhaozhao Cheng, Limei Wang, Yan Wu, Jie Lu, Shengjun Wang, Yan Xu, Wanhui Lin, Sheng Chen   +12 more
wiley   +1 more source

Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

International Journal of Cell Biology, 2013
Transport of macromolecules across the blood-brain-barrier (BBB) requires both specific and nonspecific interactions between macromolecules and proteins/receptors expressed on the luminal and/or the abluminal surfaces of the brain capillary endothelial ...
Guangqing Xiao, Liang-Shang Gan
doaj   +1 more source

From Design to Implementation: NursingUP® Board Game for Positive Nursing Practice Environments

Research in Nursing &Health, EarlyView.
ABSTRACT Positive nursing practice environments are fundamental to patient safety, care quality, and nurses’ well‐being. However, few structured and evidence‐based interventions have been developed to actively strengthen these environments and foster collaboration among nursing teams.
Soraia Cristina de Abreu Pereira, Cintia Silva Fassarella, Olga Maria Pimenta Lopes Ribeiro   +2 more
wiley   +1 more source

Human FcRn can mediate the transport across intestinal mucosal barrier and prolong the half-life of rabbit IgG in vivo

Brazilian Archives of Biology and Technology, 2015
FcRn (neonatal Fc receptor) plays an important role in IgG transportation, antigen presentation and signal transmission. In this study, the complement fixation test and flow cytometry test were performed to verify whether the heterologous antibody could ...
Guangchang Pang, Yufang Wang, Junbo Xie, Qingsen Chen, Zhihe Hu   +4 more
doaj   +1 more source

Biochemical, Biophysical, and Cellular Investigations of the Interactions of Transferrin Receptor with Transferrin and the Hereditary Hemochromatosis Protein, HFE [PDF]

, 2004
Hereditary hemochromatosis (HH) is a prevalent genetic disorder that results in the daily excess absorption of dietary iron. If untreated this disease leads to systemic organ failure and death. HH is caused by mutations to the gene coding for a protein
Giannetti, Anthony Michael
core   +1 more source

The Technology Dependence Index (TDI): Development and Validation in Neonatal and Pediatric Populations

Research in Nursing &Health, EarlyView.
ABSTRACT The survival of infants and children with complex medical conditions continues to increase, underscoring the need to quantify technology dependence more effectively. Existing measures emphasize mortality risk and fail to capture the burden of ongoing technological support.
Ashlee J. Vance, Matthew Peterson, Hayley H. Estrem, Christine A. Fortney, Sharron L. Docherty, Debra H. Brandon   +5 more
wiley   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

The structure of human CD23 and its interactions with IgE and CD21 [PDF]

, 2005
The low-affinity immunoglobulin E ( IgE) receptor, CD23 ( Fc epsilon RII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response.
Grundy, GJ, Hibbert, R G, Peter Teriete, Jonathan P. Hannan, Brian J. Sutton, Rajko Reljić, Gould, H J, Rebecca L. Beavil, Holers, V M, Hannah J. Gould, Holers, VM, Richard G. Hibbert, McDonnell, JM, Gabrielle J. Grundy, Hibbert, RG, Sutton, BJ, James M. McDonnell, Reljic, R, V. Michael Holers, Grundy, G J, Gould, HJ, Hannan, JP, Beavil, R L, Sutton, B J, Teriete, P, Beavil, RL, McDonnell, J M; id_orcid, Hannan, J P   +27 more
core   +1 more source

Hemolytic Disease of the Fetus and Newborn: Fetal RHD Genotyping, Targeted Prophylaxis, and Prenatal Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in prenatal care primarily caused by maternal alloimmunization against fetal red blood cell antigens, most commonly the D antigen. Noninvasive fetal RHD genotyping, used as a screening tool, enables targeted antenatal prophylaxis and has been implemented in several
Emilie Thorup, Steffen Thorsen, Morten Hanefeld Dziegiel, Olav Bjørn Petersen, Frederik Banch Clausen   +4 more
wiley   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source