Results 11 to 20 of about 55,479 (259)

The therapeutic age of the neonatal Fc receptor. [PDF]

Nat Rev Immunol, 2023
IgGs are essential soluble components of the adaptive immune response that evolved to protect the body from infection. Compared with other immunoglobulins, the role of IgGs is distinguished and enhanced by their high circulating levels, long half-life and ability to transfer from mother to offspring, properties that are conferred by interactions with ...
Pyzik M, Kozicky LK, Gandhi AK, Blumberg RS.   +3 more
europepmc   +5 more sources

The neonatal Fc receptor is a pan-echovirus receptor. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance Echoviruses are associated with aseptic meningitis and induce severe and sometimes fatal disease in neonates and young infants. Here, we identify the neonatal Fc receptor (FcRn) as a pan-echovirus receptor. FcRn is expressed on the surface of the human placenta, and throughout life on intestinal enterocytes, liver ...
Morosky S, Wells AI, Lemon K, Evans AS, Schamus S, Bakkenist CJ, Coyne CB.   +6 more
europepmc   +7 more sources

Expression of neonatal Fc receptor in the eye [PDF]

Investigative Opthalmology & Visual Science, 2014
PURPOSE: The neonatal Fc receptor (FcRn) plays a critical role in the homeostasis and degradation of immunoglobulin G (IgG). It mediates the transport of IgG across epithelial cell barriers and recycles IgG in endothelial cells back into the bloodstream.
Christianson, G. J., Fruttiger, M., McKenzie, J. A. G., Powner, M. B., Roopenian, D. C.   +4 more
core   +5 more sources

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity [PDF]

mAbs, 2020
The neonatal Fc receptor (FcRn) is a key membrane protein that plays an integral role in serum immunoglobulin (IgG) recycling, which extends the half-life of antibody.
Yue Sun, Alberto Estevez, Tilman Schlothauer, Aaron T. Wecksler   +3 more
doaj   +3 more sources

Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B [PDF]

Cell, 2019
Enterovirus B (EV-B), a major proportion of the genus Enterovirus in the family Picornaviridae, is the causative agent of severe human infectious diseases. Although cellular receptors for coxsackievirus B in EV-B have been identified, receptors mediating virus entry, especially the uncoating process of echovirus and other EV-B remain obscure.
Zhao, Xin, Zhang, Guigen, Liu, Sheng, Chen, Xiangpeng, Peng, Ruchao, Dai, Lianpan, Qu, Xiao, Li, Shihua, Song, Hao, Gao, Zhengrong, Yuan, Pengfei, Liu, Zhiheng, Li, Changyao, Shang, Zifang, Li, Yan, Zhang, Meifan, Qi, Jianxun, Wang, Han, Du, Ning, Wu, Yan, Bi, Yuhai, Gao, Shan, Shi, Yi, Yan, Jinghua, Zhang, Yong, Xie, Zhengde, Wei, Wensheng, Gao, George F.   +27 more
openaire   +4 more sources

Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier [PDF]

Nature Communications
The blood-brain barrier (BBB) restricts efficient penetration of systemically delivered therapeutic antibodies into the brain, limiting the development of this class of drugs to treat neurodegenerative diseases.
Julien Lafrance-Vanasse, Shraddha S. Sadekar, Yanli Yang, Daniela Bumbaca Yadav, William J. Meilandt, Monica K. Wetzel-Smith, Hao Cai, Susan R. Crowell, Van Nguyen, Vivian Lee, Ben Chih, Mandy Kwong, Pamela Chan, Sara Santagostino, Donna Lee, Shan Chung, Greg A. Lazar, James A. Ernst, Jasvinder K. Atwal   +18 more
doaj   +2 more sources

Activation of the JNK/MAPK Signaling Pathway by TGF-β1 Enhances Neonatal Fc Receptor Expression and IgG Transcytosis [PDF]

Microorganisms, 2021
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the foetus or newborn and protects the IgG from degradation. FcRn is expressed in several porcine tissues and cell types and its expression levels are regulated by immune and ...
Shaoju Qian, Chenxi Li, Xi Liu, Xiangchao Jia, Yuncai Xiao, Zili Li   +5 more
doaj   +2 more sources

Neonatal Fc Receptor-Targeted Therapies in Neurology. [PDF]

Neurotherapeutics, 2022
Autoantibodies are increasingly recognized for their pathogenic potential in a growing number of neurological diseases. While myasthenia gravis represents the prototypic antibody (Ab)-mediated neurological disease, many more disorders characterized by Abs targeting neuronal or glial antigens have been identified over the past two decades.
Nelke C, Spatola M, Schroeter CB, Wiendl H, Lünemann JD.   +4 more
europepmc   +4 more sources

The neonatal Fc receptor in mucosal immune regulation [PDF]

Scandinavian Journal of Immunology, 2021
AbstractThe neonatal Fc receptor (FcRn) was first recognized for its role in transfer of maternal IgG to the foetus or newborn, providing passive immunity early in life. However, it has become clear that the receptor is versatile, widely expressed and plays an indispensable role in both immunological and non‐immunological processes throughout life. The
Kristin Hovden Aaen, Aina Karen Anthi, Inger Sandlie, Jeannette Nilsen, Simone Mester, Jan Terje Andersen   +5 more
openaire   +2 more sources

Neonatal Fc Receptor: From Immunity to Therapeutics [PDF]

Journal of Clinical Immunology, 2010
The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells. Its function is evident in early life in
Kuo, Timothy Ting-Chang, Baker, Kristi, Yoshida, Masaru, Qiao, Shuo-Wang, Aveson, Victoria G., Lencer, Wayne, Blumberg, Richard   +6 more
openaire   +3 more sources