Results 31 to 40 of about 1,686,776 (208)

The Roles of Membrane Rafts in CD32A-Mediated Phagocytosis [PDF]

, 2007
Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to ...
Periasamy Selvaraj, Timothy P. Tolentino, Cheng Zhu   +2 more
core   +1 more source

Neonatal Fc Receptor: From Immunity to Therapeutics [PDF]

, 2010
The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in ...
Yoshida, Masaru, Lencer, Wayne, Wayne I. Lencer, Richard S. Blumberg, Aveson, Victoria G., Masaru Yoshida, Blumberg, Richard, Victoria G. Aveson, Shuo-Wang Qiao, Timothy T. Kuo, Qiao, Shuo-Wang, Baker, Kristi, Kristi Baker, Kuo, Timothy Ting-Chang   +13 more
core   +1 more source

The Ligands for Human IgG and Their Effector Functions

Antibodies, 2019
Activation of the humoral immune system is initiated when antibodies recognize an antigen and trigger effector functions through the interaction with Fc engaging molecules.
Steven W. de Taeye, Theo Rispens, Gestur Vidarsson   +2 more
doaj   +1 more source

Isolation and Identification of Porcine Deltacoronavirus and Alteration of Immunoglobulin Transport Receptors in the Intestinal Mucosa of PDCoV-Infected Piglets

Viruses, 2020
Porcine deltacoronavirus (PDCoV) is a porcine enteropathogenic coronavirus that causes watery diarrhea, vomiting, and frequently death in piglets, causing serious economic losses to the pig industry.
Shaoju Qian, Xiangchao Jia, Zitong Gao, Weida Zhang, Qingrong Xu, Zili Li   +5 more
doaj   +1 more source

Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway [PDF]

, 2003
Background: The regulation of platelet function by pharmacological agents that modulate platelet signaling haspharmacolo proven a successful approach to the prevention of thrombosis.
Cicmil, M, C. M. Williams, G. P. Hubbard, T. Sage, Stevens, J M; id_orcid, P. A. Jordan, J. M. Gibbins, M. Cicmil, Sage, T, Gibbins, J.M., Williams, C M, Gibbins, J M, Jordan, P A, Lovegrove, J A, Hubbard, G P, J. A. Lovegrove, J. M. Stevens, Stevens, J.M., Williams, C.M., Jordan, P.A., Lovegrove, J.A., Hubbard, G.P., Cicmil, M., Sage, T.   +23 more
core   +1 more source

Expression of Neonatal Fc Receptor in the eye. [PDF]

, 2014
Purpose: The neonatal Fc receptor (FcRn) plays a critical role in the homeostasis and degradation of immunoglobulin G (IgG). It mediates the transport of IgG across epithelial cell barriers and recycles IgG in endothelial cells back into the blood stream.
Powner, Michael B, McKenzie, Jenny A G, Fruttiger, Marcus, Roopenian, Derry C, Christianson, Gregory J   +4 more
core   +2 more sources

Long-term safety, tolerability, and efficacy of subcutaneous efgartigimod PH20 in generalized myasthenia gravis: final results from a phase 3 open-label extension study (ADAPT-SC+)

Frontiers in Neurology
BackgroundEfgartigimod is a human immunoglobulin (IgG1) antibody Fc fragment that reduces IgG levels through neonatal Fc receptor blockade. ADAPT-SC+ assessed the long-term safety, tolerability, and efficacy of subcutaneous (SC) efgartigimod PH20 in ...
Andreas Meisel, Carlo Antozzi, Ratna Bhavaraju-Sanka, Jan L. De Bleecker, Wan-Yi Huang, Rosa Hermina Jimenez, Fien M. Verhamme, Ming Jiang, Li Liu, Denis Korobko, Anna Kostera-Pruszczyk, Kimiaki Utsugisawa, Jan J. G. M. Verschuuren, Tuan Vu, Heinz Wiendl, James F. Howard   +15 more
doaj   +1 more source

Benefits and Risks of IgG Transplacental Transfer

Diagnostics, 2020
Maternal passage of immunoglobulin G (IgG) is an important passive mechanism for protecting the infant while the neonatal immune system is still immature and ineffective.
Anca Marina Ciobanu, Andreea Elena Dumitru, Nicolae Gica, Radu Botezatu, Gheorghe Peltecu, Anca Maria Panaitescu   +5 more
doaj   +1 more source

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

mAbs, 2022
A conventional antibody targeting a soluble antigen in circulation typically requires a huge dosage and frequent intravenous administration to neutralize the antigen.
Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori, Tomoyuki Igawa   +16 more
doaj   +1 more source

Additional file 3: of Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy

, 2018
Figure S2. Human PD1-Fc-OX40L ARC binds via Fc and OX40L domains using ELISA, and to the neonatal receptor FcRn using SPR.
Taylor Schreiber (6100496), Josiah Hornblower (6100490), George Fromm (561951), Kellsey Johannes (6100478), Arpita Patel (6100484), Suresh de Silva (166654)   +5 more
core   +1 more source