Results 41 to 50 of about 55,479 (259)

Targeting the Neonatal Fc Receptor for Antigen Delivery Using Engineered Fc Fragments [PDF]

The Journal of Immunology, 2008
AbstractThe development of approaches for Ag delivery to the appropriate subcellular compartments of APCs and the optimization of Ag persistence are both of central relevance for the induction of protective immunity or tolerance. The expression of the neonatal Fc receptor, FcRn, in APCs and its localization to the endosomal system suggest that it might
Mi, Wentao, Wanjie, Sylvia, Lo, Su Tang, Gan, Zhuo, Pickl-Herk, Beatrix, Ober, Raimund J., Ward, E. Sally   +6 more
openaire   +2 more sources

Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes [PDF]

, 2015
Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition.
Aardema, Alves, Arsic, Asselin, Carluccio, Catov, Challis, Chen, Cheng, Cheng, Cheng, Cheng, Cherny, Chu, Crane, D.C. Wathes, D.R.E. Abayasekara, Flynn, Goncalves, Guillou, Herath, Jabbour, Karsch, Kim, Klein, Lamont, Lee, Leung, Lewis, Lunn, M. Elmes, Nielsen, Noble, Poyser, Reddy, Rimoldi, Robinson, S. Kirkup, Sharp, Smith, Smith, Thorburn, Villa, Wang, Wathes, Wendell, Whittle, Witkin, Z. Cheng, Zhang   +49 more
core   +2 more sources

Taking the Hinge off: An Approach to Effector-Less Monoclonal Antibodies

Antibodies, 2020
A variety of Fc domain engineering approaches for abrogating the effector functions of mAbs exists. To address some of the limitations of the current Fc domain silencing approaches, we are exploring a less commonly considered option which relies on the ...
Jamie Valeich, Dan Boyd, Manu Kanwar, Daniel Stenzel, Deblina De Ghosh, Arpa Ebrahimi, James Woo, Jenny Wang, Alexandre Ambrogelly   +8 more
doaj   +1 more source

Neonatal Fc receptor promoter gene polymorphism does not predict pharmacokinetics of IVIg or the clinical course of GBS [PDF]

, 2016
Treatment of Guillain-Barré syndrome with a standard course of high-dose intravenous immunoglobulin (IVIg) results in a variable clinical recovery which is associated with changes in serum IgG levels after treatment. The neonatal Fc-receptor protects IgG
Doorn, P.A. (Pieter) van, Fokkink, W.-J.R. (Willem-Jan), Haarman, A.E.G. (Annechien E. G.), Huizinga, R. (Ruth), Jacobs, B.C. (Bart), Rijs, W. (Wouter) van, Tio-Gillen, A.P. (Anne)   +6 more
core   +1 more source

Selection of Nanobodies that Target Human Neonatal Fc Receptor [PDF]

Scientific Reports, 2013
FcRn is a key player in several immunological and non-immunological processes, as it mediates maternal-fetal transfer of IgG, regulates the serum persistence of IgG and albumin, and transports both ligands between different cellular compartments. In addition, FcRn enhances antigen presentation.
Andersen, Jan Terje, Gonzalez-Pajuelo, Maria, Foss, Stian, Landsverk, Ole J. B., Pinto, Debora, Szyroki, Alexander, de Haard, Hans J., Saunders, Michael, Vanlandschoot, Peter, Sandlie, Inger   +9 more
openaire   +3 more sources

Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells

Journal of Translational Medicine, 2018
Background Fibrinogen is a central player in the blood coagulation cascade and one of the most abundant plasma proteins. This glycoprotein also triggers important events (e.g., cell spreading, the respiratory burst and degranulation) in neutrophil cells ...
Tiziana Alberio, Greta Forlani, Marta Lualdi, Giovanna Tosi, Roberto S. Accolla, Mauro Fasano   +5 more
doaj   +1 more source

Neonatal Fc Receptor Promotes Immune Complex–Mediated Glomerular Disease [PDF]

Journal of the American Society of Nephrology, 2014
The neonatal Fc receptor (FcRn) is a major regulator of IgG and albumin homeostasis systemically and in the kidneys. We investigated the role of FcRn in the development of immune complex-mediated glomerular disease in mice. C57Bl/6 mice immunized with the noncollagenous domain of the α3 chain of type IV collagen (α3NC1) developed albuminuria associated
Florina, Olaru, Wentian, Luo, Hani, Suleiman, Patricia L, St John, Linna, Ge, Adam R, Mezo, Andrey S, Shaw, Dale R, Abrahamson, Jeffrey H, Miner, Dorin-Bogdan, Borza   +9 more
openaire   +2 more sources

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]

, 2019
Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang, Fang-Hoover, June, Freed, Daniel C, Fu, Tong-Ming, Li, Fengsheng, Pereira, Lenore, Petitt, Matthew, Tabata, Takako, Wang, Dai   +8 more
core   +1 more source

Engineered clearing agents for the selective depletion of antigen-specific antibodies

Nature Communications, 2017
The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn, to ...
Siva Charan Devanaboyina, Priyanka Khare, Dilip K. Challa, Raimund J. Ober, E. Sally Ward   +4 more
doaj   +1 more source

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice

Cell Reports, 2015
Immunoglobulin G (IgG) antibodies are major drivers of autoimmune pathology, but they are also used in the form of intravenous IgG (IVIg) therapy to suppress autoantibody activity. To identify the pathways underlying human autoantibody and IVIg activity,
Inessa Schwab, Anja Lux, Falk Nimmerjahn
doaj   +1 more source