Results 51 to 60 of about 55,479 (259)
mAbs, 2023 The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders.
Jason Tien +13 more
doaj +1 more source
Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy. [PDF]
, 2015 The low molecular weight protein tyrosine phosphatase (LMPTP), encoded by the ACP1 gene, is a ubiquitously expressed phosphatase whose in vivo function in the heart and in cardiac diseases remains unknown.
Al-Habeeb, Waleed +20 more
core +2 more sources
Interactions of IgG1 CH2 and CH3 Domains with FcRn [PDF]
, 2014 Antibody fragments are emerging as promising biopharmaceuticals because of their relatively small size and other unique properties. However, when compared to full-size antibodies, most of the current antibody fragments of VH or VL display greatly reduced
Dimiter S. Dimitrov +4 more
core +7 more sources
Effects of receptor dimerization on the interaction between the class I major histocompatibility complex-related Fc receptor and IgG [PDF]
, 1995 The neonatal Fc receptor (FcRn) transports maternal IgG from ingested milk in the gut to the bloodstream of newborn mammals. An FcRn dimer was observed in crystals of the receptor alone and of an FcRn-Fc complex, but its biological relevance was unknown.
Bjorkman, Pamela J. +2 more
core +1 more source
Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms [PDF]
Journal of Biological Chemistry, 2014 We report the three-dimensional structure of human neonatal Fc receptor (FcRn) bound concurrently to its two known ligands. More particularly, we solved the crystal structure of the complex between human FcRn, wild-type human serum albumin (HSA), and a human Fc engineered for improved pharmacokinetics properties (Fc-YTE). The crystal structure of human
Vaheh, Oganesyan +6 more
openaire +2 more sources
Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids [PDF]
, 2016 Inward rectifier potassium (Kir) channel activity is controlled by plasma membrane lipids. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) binding to a primary site is required for opening of classic inward rectifier Kir2.1 and Kir2.2 channels, but ...
Anna Stary-Weinzinger +55 more
core +2 more sources
The Ligands for Human IgG and Their Effector Functions
Antibodies, 2019 Activation of the humoral immune system is initiated when antibodies recognize an antigen and trigger effector functions through the interaction with Fc engaging molecules.
Steven W. de Taeye +2 more
doaj +1 more source
Benefits and Risks of IgG Transplacental Transfer
Diagnostics, 2020 Maternal passage of immunoglobulin G (IgG) is an important passive mechanism for protecting the infant while the neonatal immune system is still immature and ineffective.
Anca Marina Ciobanu +5 more
doaj +1 more source
Intestinal macromolecular transport supporting adaptive immunity [PDF]
, 2019 The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
core +2 more sources
Efficient mucosal vaccination mediated by the neonatal Fc receptor [PDF]
Nature Biotechnology, 2011 Almost all infectious diseases are initiated at mucosal surfaces, yet intramuscular or subcutaneous vaccination usually provides only minimal protection at sites of infection owing to suboptimal activation of the mucosal immune system. The neonatal Fc receptor (FcRn) mediates the transport of IgG across polarized epithelial cells lining mucosal ...
Ye, L +4 more
openaire +2 more sources