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Induction of neonatal Fc receptor-mediated tolerance to therapeutic factor VIII in Hemophilia A
Alejandra Reyes Ruiz
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Regulation of dendritic cell function by Fc-γ-receptors and the neonatal Fc receptor
Molecular Immunology, 2021Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among those receptors, Fc receptors (FcRs) are triggered by the Fc region of antibodies produced during adaptive immunity. In this review, the role of FcγR and neonatal Fc receptor (FcRn) in DC immunity will be discussed.
Justine D. Mintern +3 more
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FcRn: the neonatal Fc receptor comes of age [PDF]
Nature Reviews Immunology, 2007 The neonatal Fc receptor for IgG (FcRn) has been well characterized in the transfer of passive humoral immunity from a mother to her fetus. In addition, throughout life, FcRn protects IgG from degradation, thereby explaining the long half-life of this class of antibody in the serum. In recent years, it has become clear that FcRn is expressed in various
Roopenian, D C, Akilesh, S
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Crystal structure of the complex of rat neonatal Fc receptor with Fc
Nature, 1994The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the bloodstream of the newborn. FcRn is structurally similar to class I major histocompatibility complex (MHC) molecules, despite differences in the ligands they bind (the Fc portion of IgG and antigenic peptides, respectively).
Burmeister, Wilhelm P. +2 more
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Synonymous nucleotide substitutions in the neonatal Fc receptor
Immunogenetics, 2002The neonatal Fc receptor (FcRn) is a key receptor involved in the transcytosis of IgG across the maternal-fetal barrier. The level of IgG varies considerably among newborn infants. Since other Fc gamma receptors show single nucleotide functional variants, we determined whether common variant alleles exist for the FcRn.
Gregory A. Denomme +2 more
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Neonatal Fc Receptor Inhibitor Therapeutics in Neuromuscular Disease
Journal of Clinical Neuromuscular Disease, 2023Abstract The Neonatal Fc Receptor (FcRn) is integral to a wide variety of processes including IgG recycling, serum albumin turnover, and bacterial opsonization. Thus, targeting FcRn will increase antibody degradation including pathogenic IgGs.
Mustafa Jaffry +6 more
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Polymorphisms of Neonatal Fc Receptor in Cynomolgus and Rhesus Macaques
Drug Metabolism and Pharmacokinetics, 2014Neonatal Fc receptor (FcRn), a heterodimer of MHC class I-like protein and β2-microglobulin, encoded by FCGRT and B2M, respectively, is important for recycling immunoglobulin G (IgG) antibodies by binding with the Fc region of IgG. Cynomolgus macaques are important animal species used in the evaluation of therapeutic antibodies, largely due to sequence
Yasuhiro Uno +2 more
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Isolation of the gene encoding the bovine neonatal Fc receptor
Veterinary Immunology and Immunopathology, 2005The role of an IgG-Fc receptor (FcRn) that resembles a class I MHC Ag in transporting IgGs through epithelial cells was recently shown in selected species. Here we report our preliminary characterization of a clone encoding the alpha chain of the bovine FcRn from a BAC library.
Márton Doleschall +4 more
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Targeting neonatal Fc receptor: potential clinical applications in pregnancy
Ultrasound in Obstetrics & Gynecology, 2022ABSTRACTThe neonatal Fc receptor (FcRn) plays an important role in the transfer of the immunoglobulin G isotype (IgG) from the mother to the fetus. FcRn expressed on endothelial cells also binds to IgG and albumin, regulating the circulating half‐lives of these proteins. Alloimmune and autoimmune IgG antibodies have been implicated in various perinatal
K. J. Moise +3 more
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