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The neonatal Fc receptor (FcRn) expression in the human skin
Virchows Archiv, 2007The neonatal Fc receptor, FcRn, has a wide expression within the human body, including adult cells; however, it is not ubiquitously expressed (reviewed in [2]). The receptor is involved both in IgG transcytosis as well as recycling, being able to bind both free and antigen complexed IgG molecules (reviewed in [4]). Cauza et al.
Petru Cianga +4 more
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The neonatal Fc receptor (FcRn) is expressed in the bovine lung
Veterinary Immunology and Immunopathology, 2004In neonatal calves, maternal immunoglobulin (Ig) is transferred into respiratory secretion which contributes to protection against pathogens. The early predominance of IgG1 in respiratory tract secretions is progressively reduced in favor of IgA by age but in the lower, bronchoalveolar system secreted IgG remains the dominant secreted Ig even in ...
Laszlo V. Frenyo +5 more
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The Fc Receptor for IgG (FcγRII; CD32) on human neonatal B lymphocytes
Human Immunology, 2001B cells express an Fc receptor for IgG (FcgammaRII; CD32) which is involved in feedback inhibition of antibody production. Engagement of FcgammaRII during ligation of the antigen receptor provides an inhibitory signal. FcgammaRII exists as several isoforms, with FcgammaRIIb (which carries an immunoreceptor tyrosine-based inhibition motif; ITIM) being ...
Jessup, C. +6 more
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The neonatal Fc receptor and DPP4 are human astrovirus receptors
AbstractHuman astroviruses (HAstV) are major global causes of gastroenteritis, but little is known about host factors required for their cellular entry. Here, we utilized complementary CRISPR-Cas9-based knockout and activation screening approaches and identified neonatal Fc receptor (FcRn) and dipeptidyl-peptidase IV (DPP4) as entry factors for HAstV ...Harshad, Ingle +10 more
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Distribution of rat neonatal Fc receptor in the principal organs of neonatal and pubertal rats
Journal of Receptors and Signal Transduction, 2013The neonatal Fc receptor (FcRn) mediates the transfer of IgG and albumin, also protects them from catabolism. This study characterized the expression of FcRn in different organs of neonatal and pubertal rats by reverse transcription-PCR (RT-PCR) and immunohistochemistry, demonstrates that FcRn is expressed in liver, kidney, intestine, heart, lung ...
Tian, Zehua +2 more
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[Neonatal Fc receptor, key control of immunoglobulins biodistribution].
Medecine sciences : M/S, 2009In 1969, Brambell, while studying the long serum half-life of IgG and their ability to cross the materno-foetal barrier, attributed these two properties to the existence of a specific Fc receptor, which was later denominated FcRn for neonatal Fc receptor. The resolution of its structure revealed that it is a MHC class-I-like molecule.
Magdelaine-Beuzelin, Charlotte +2 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen +2 more
exaly
Inhibition of neonatal Fc receptor as a treatment for immune thrombocytopenia
The Lancet, 2023Syed, Mahamad, Donald M, Arnold
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