Results 41 to 50 of about 7,511 (210)
Implications of Fc Neonatal Receptor (FcRn) Manipulations for Transplant Immunotherapeutics
Transplantation, 2019 Alloimmune injury to allografts is mediated by pathogenic donor-specific alloantibodies, usually of the IgG isotype. Currently, strategies used to reduce donor-specific alloantibodies are collectively called desensitization. Despite successes, these treatments have limited efficacy and can be associated with adverse events, infectious complications ...
Stanley C. Jordan +2 more
openalex +5 more sources
Human IgE does not bind to human FcRn
Scientific Reports, 2022 The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to environmental antigens.
Maximilian Brinkhaus +6 more
doaj +1 more source
mAbs, 2021 Therapeutic immunoglobulin G (IgG) antibodies have comparatively long half-lives because the neonatal Fc receptor (FcRn) binds to the IgG Fc at acidic pH in the endosome and protects IgG from degradation.
Takuo Suzuki +3 more
doaj +1 more source
THE FC-RECEPTOR NEONATAL (FCRN) TRAFFICS THROUGH THE COMMON ENDOSOME IN MUCOSAL EPITHELIAL CELLS
Journal of Pediatric Gastroenterology and Nutrition, 2005 Elizabeth H. Yen +3 more
openalex +3 more sources
Dissection of the Neonatal Fc Receptor (FcRn)-Albumin Interface Using Mutagenesis and Anti-FcRn Albumin-blocking Antibodies [PDF]
Journal of Biological Chemistry, 2014 Albumin is the most abundant protein in blood and plays a pivotal role as a multitransporter of a wide range of molecules such as fatty acids, metabolites, hormones, and toxins. In addition, it binds a variety of drugs. Its role as distributor is supported by its extraordinary serum half-life of 3 weeks.
Kine Marita Knudsen Sand +10 more
openalex +7 more sources
Neonatal EEG graded for severity of background abnormalities in hypoxic-ischaemic encephalopathy [PDF]
Sci Data 10, 129 (2023), 2022 This report describes a set of neonatal electroencephalogram (EEG) recordings graded according to the severity of abnormalities in the background pattern. The dataset consists of 169 hours of multichannel EEG from 53 neonates recorded in a neonatal intensive care unit.
arxiv +1 more source
Human FcRn Tissue Expression Profile and Half-Life in PBMCs
Biomolecules, 2019 System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically ...
Yao-Yun Fan +5 more
doaj +1 more source
American Journal of HematologyAbstractThe neonatal fragment crystallizable (Fc) receptor (FcRn) transports IgG across mucosal surfaces and the placenta and protects IgG from degradation. Numerous clinical trials are investigating therapeutic FcRn inhibition for various immune‐mediated neuromuscular and rheumatologic conditions; however, FcRn inhibition also represents a potential ...
Jeremy W. Jacobs +17 more
openalex +3 more sources
mAbs, 2023 The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders.
Jason Tien +13 more
doaj +1 more source
Tissues Expression, Polymorphisms Identification of FcRn Gene and Its Relationship with Serum Classical Swine Fever Virus Antibody Level in Pigs [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 Neonatal Fc receptor (FcRn) gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G (IgG) and is responsible for IgG transport and stabilization.
Liu Yang +8 more
doaj +1 more source