Results 91 to 100 of about 455,818 (276)

Treatment of Neonatal Seizures

, 1989
The rapid sequential phenobarbital treatment of neonatal seizures was examined in 120 newborns and the efficacy of high dose monotherapy was compared with the addition of a second anticonvulsant for persistent seizure ...
J Gordon Millichap
core   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Task Force on Neonatal Seizures

, 2023
Seizures are common in neonates, but there is substantial management variability. The Neonatal Task Force of the International League Against Epilepsy (ILAE) developed evidence-based recommendations about antiseizure medication (ASM) management in ...
Renée A. Shellhaas, Yozawitz, Elissa G, Geraldine Boylan, Linda S. De Vries, De Vries, Linda S, Shany, Eilon, Abend, Nicholas S, Eli M. Mizrahi, Shellhaas, Renée A, Terrie Inder, Noyman, Iris, Hans Hartmann, Samia, Pauline, Ronit M. Pressler, Inder, Terrie, Kollencheri Puthenveettil Vinayan, Boylan, Geraldine, Stéphan Auvin, Magda L. Nunes, Alberto Espeche, Lakshmi Nagarajan, Pauline Samia, Auvin, Stéphan, Wilmshurst, Jo M, Moshé, Solomon L, Subota, Ann, Angelina Kakooza‐Mwesige, Pressler, Ronit M, Cecil D. Hahn, Maria Roberta Cilio, Chahnez Charfi Triki, Kakooza-Mwesige, Angelina, Nicholas S. Abend, Francesco Brigo, Jette, Nathalie, Silke Mader, Cilio, Maria Roberta, Mizrahi, Eli M, Tammy Tsuchida, Maurizio Elia, Cilio, Maria-Roberta, Brigo, Francesco, Hartmann, Hans, Espeche, Alberto, Mader, Silke, Jo M. Wilmshurst, Tsuchida, Tammy, Vinayan, Kollencheri Puthenveettil, Nagarajan, Lakshmi, Ann Subota, Elissa G. Yozawitz, Elia, Maurizio, Eilon Shany, Iris Noyman, Triki, Chahnez Charfi, Nunes, Magda L, Nathalie Jette, Solomon L. Moshé, Hahn, Cecil D   +58 more
core   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Levetiracetam versus Phenobarbitone in Neonatal Seizures - An Open label Randomized Controlled Trial

RGUHS Journal of Nursing Sciences
BackgroundnbspPhenobarbitone is the traditional first-line anticonvulsant for neonatal seizures while levetiracetam a newer anti-epileptic has uncertain efficacy in comparisonObjectivenbspTo evaluate the efficacy and safety of ...
Nikhil D Kulkarni, Suman Rao P N, B Lakshmi Parvathi, Swarnarekha Bhat   +3 more
doaj   +1 more source

Neonatal Seizure Models to Study Epileptogenesis

Frontiers in Pharmacology, 2018
Current therapeutic strategies for epilepsy include anti-epileptic drugs and surgical treatments that are mainly focused on the suppression of existing seizures rather than the occurrence of the first spontaneous seizure.
Yuka Kasahara, Yuji Ikegaya, Ryuta Koyama   +2 more
doaj   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia

Frontiers in Immunology, 2019
Recent studies suggest that mild hypoxia-induced neonatal seizures can trigger an acute neuroinflammatory response leading to long-lasting changes in brain excitability along with associated cognitive and behavioral deficits.
Sean Quinlan, Paula Merino-Serrais, Paula Merino-Serrais, Alessandra Di Grande, Heiko Dussmann, Jochen H. M. Prehn, Jochen H. M. Prehn, Tríona Ní Chonghaile, David C. Henshall, David C. Henshall, David C. Henshall, Eva M. Jimenez-Mateos, Eva M. Jimenez-Mateos   +12 more
doaj   +1 more source

Neonatal Seizures and Syndromes [PDF]

Epilepsia, 2002
Summary:Neonatal seizures frequently accompany neonatal encephalopathies. Seizures occur in ∼1.8–5/1,000 live births in this country and are caused by virtually any condition that affects neonatal brain function. This review provides a simple classification of seizures and emphasizes that many abnormal intermittent behaviors in this age group are not ...
openaire   +2 more sources