Results 101 to 110 of about 455,818 (276)
Advanced Science, EarlyView.Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng +15 more
wiley +1 more source
New trends in neonatal seizures
, 2004 Seizures are very frequent in neonatal period. A seizure is an abrupt alteration in neurological function of the newborn and it can be due to many different causes.
Claudio De Felice +3 more
core +1 more source
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
Advanced Science, EarlyView.Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng +14 more
wiley +1 more source
Neonatal Seizures: A Comprehensive study [PDF]
, 2011 INTRODUCTION: Seizures are the most distinctive manifestation of neurologic dysfunction in the newborn infant. Moreover, neonatal seizures often herald potentially devastating forms of brain injury.
Senthilkumar, J
core
KCNQ2 Encephalopathy and Neonatal Seizures
, 2011 Researchers from centers in Belgium and Australia analyzed 80 patients with unexplained neonatal or early infantile seizures and associated psychomotor retardation for KCNQ2 ...
J Gordon Millichap, Millichap, J. Gordon
core +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
Archives of Disease in Childhood - Fetal and Neonatal Edition, 1998 D, Evans, M, Levene
openaire +2 more sources
Advanced Science, EarlyView.CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai +15 more
wiley +1 more source
Management of Neonatal Seizures
, 2008 The generally accepted clinical approaches to neonatal seizures were determined by questionnaires completed by pediatric neurologists and neonatologists representing all the pediatric neurology units and all departments of neonatology in Isrrael, and ...
J Gordon Millichap, Millichap, J. Gordon
core +1 more source