Results 81 to 90 of about 774,272 (298)

Solitary metastasis to the head of the pancreas from lung adenocarcinoma mimicking pancreatic ductal adenocarcinoma: A case report

Radiology Case Reports
Solitary pancreatic metastasis is a rare cause of pancreatic neoplasm. Pancreatic ductal adenocarcinoma is the primary differential consideration when a solitary pancreatic mass is diagnosed, as it is the most common solitary solid pancreatic neoplasm. A
Mostafa Amor, M. Azfar Siddiqui, Irfan Amir Kazi, Asad Kabir, Ayesha Nasrullah   +4 more
doaj   +1 more source

Thyroid in the Thigh – A Rare Presentation of Follicular Carcinoma

Online Journal of Health & Allied Sciences, 2021
Follicular carcinoma is the second commonest thyroid malignancy. Blood borne metastasis is common with spread to the lungs and bones. However, metastasis to the skeletal muscles is an extremely rare manifestation.
Mourouguessine Vimal, Neha Sikdar
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Distant organ metastasis patterns in lung cancer patients with pancreatic metastasis – a cluster analysis

, 2022
INTRODUCTION: Pancreatic metastasis of lung cancer is rare, but the narrowing or obstruction of the biliary tract from pancreatic metastases limits the choice of antitumour agents.
Satoh, Hiroaki, Toshihiro Shiozawa, Miyazaki, Kunihiko, Nobuyuki Hizawa, Okauchi, Shinichiro, Shiozawa, Toshihiro, Shinichiro Okauchi, Hiroaki Satoh, Kunihiko Miyazaki, Hizawa, Nobuyuki   +9 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Non-Coding RNAs of Extracellular Vesicles: Key Players in Organ-Specific Metastasis and Clinical Implications

, 2022
Extracellular vesicles (EVs) are heterogeneous membrane-encapsulated vesicles released by most cells. They act as multifunctional regulators of intercellular communication by delivering bioactive molecules, including non-coding RNAs (ncRNAs).
Liu, Yu Xuan, Yu Xuan Liu, Zhaowu Ma, Xiao-Ping Tan, Cai-Hua Zhang, Qian Jiang, Tan, Xiao-Ping, Li, Du, Lingzhi Wang, Xu, Yan, Zhang, Cai-Hua, Li, Zhi-Yuan, Wang, Lingzhi, Ma, Zhaowu, Zhi-Yuan Li, Jiang, Qian, Du Li, Yan Xu   +17 more
core   +1 more source

Ocular Metastasis in Lung Cancer: a Retrospective Analysis in a Single Chinese Hospital and Literature Review

Chinese Journal of Lung Cancer, 2017
Background and objective Eye is a rare site of lung cancer metastasis, and ocular metastasis is one of the largest challenges to cancer patients' quality of life (QOL).
Yan XU, Yiduo SUN, Jing ZHAO, Minjiang CHEN, Lina JIANGDE, Longyun LI, Wei ZHONG, Mengzhao WANG   +7 more
doaj   +1 more source

Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis. [PDF]

Sci Rep, 2021
Kaemmer CA, Umesalma S, Maharjan CK, Moose DL, Narla G, Mott SL, Zamba GKD, Breheny P, Darbro BW, Bellizzi AM, Henry MD, Quelle DE.   +11 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source