Results 91 to 100 of about 8,440,114 (317)

Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment. [PDF]

, 2017
CXCR1 and CXCR2 chemokine receptors and their ligands (CXCL1/2/3/7/8) play an important role in tumor progression. Tested to date CXCR1/2 antagonists and chemokine-targeted antibodies were reported to affect malignant cells in vitro and in animal models.
Alexeev, Vitali, Allegretti, Marcello, De Pizzol, Maria, Igoucheva, Olga, Jonas, Rebecca, Kemp, Daria Marley, Larijani, Mary, Lash, Elizabeth, Pidich, Alyson, Sato, Takami, Terai, Mizue   +10 more
core   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

C030 | GENOTYPE-PHENOTYPE CORRELATES AND OUTCOMES OF EXTRAMEDULLARY ACUTE MYELOID LEUKEMIA

Haematologica
Background: Genomic abnormalities associated with extramedullary (EM) acute myeloid leukemia (eAML) and their impact on clinical outcomes are not well understood since previous studies were limited to small case series with controversial results.
G.G. Loscocco, F. Mannelli, M. Piccini, B. Scappini, F. Crupi, G. Ciolli, L. Fasano, G. Rotunno, F. Pancani, C. Maccari, L. Signori, P. Guglielmelli, A.M. Vannucchi   +12 more
doaj  

P632: ORAL AND GUT MICROBIAL DIVERSITY CORRELATES WITH PROGNOSTIC FEATURES IN CHRONIC LYMPHOCYTIC LEUKEMIA

HemaSphere, 2022
M. Szelest, M. Paziewska, M. Kiełbus, M. Masternak, J. Zaleska, E. Wawrzyniak, E. Kalicińska, P. Jabłonowska, T. Wróbel, A. Wolska-Washer, J. Z. Błoński, K. Giannopoulos   +11 more
doaj   +1 more source

NPCMF: Nearest Profile-based Collaborative Matrix Factorization method for predicting miRNA-disease associations

BMC Bioinformatics, 2019
Background Predicting meaningful miRNA-disease associations (MDAs) is costly. Therefore, an increasing number of researchers are beginning to focus on methods to predict potential MDAs.
Ying-Lian Gao, Zhen Cui, Jin-Xing Liu, Juan Wang, Chun-Hou Zheng   +4 more
doaj   +1 more source

The fractal urban coherence in biourbanism: the factual elements of urban fabric [PDF]

, 2013
This article is available online and will be inserted in also printed format in the Journal in October 2013.During the last few decades, modern urban fabric lost some very important elements, only because urban design and planning turned out to be ...
Tracada, Eleni
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

P1258: MOLECULAR CYTOGENETICS CHARACTERIZATION OF CLASSICAL HODGKIN LYMPHOMA. ROL OF 9P24.1 (PD-L1/PD-L2) POLYSOMIES

HemaSphere, 2022
M. García-Montenegro, M. Narbaitz, M. F. Metrebian, A. Pavlovsky, I. Slavutsky   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source