Results 1 to 10 of about 88,339 (121)

Heterogeneity of Circulating Tumor Cell Neoplastic Subpopulations Outlined by Single-Cell Transcriptomics [PDF]

Cancers, 2021
Fatal metastasis occurs when circulating tumor cells (CTCs) disperse through the blood to initiate a new tumor at specific sites distant from the primary tumor. CTCs have been classically defined as nucleated cells positive for epithelial cell adhesion molecule and select cytokeratins (EpCAM/CK/DAPI), while negative for the common lymphocyte marker ...
Christine M. Pauken, Shelby Ray Kenney, Kathryn J. Brayer, Yan Guo, Ursa A. Brown-Glaberman, Dario Marchetti   +5 more
openaire   +3 more sources

Circulating hypergranular neoplastic cells: not always leukemic promyelocytes [PDF]

Blood, 2017
![Figure][1] A 39-year-old woman presented with severe low back pain, hepatosplenomegaly, leukocytosis (15.9 × 109/L), anemia (7.3 g/dL), thrombocytopenia (48 × 109/L), and elevated serum tryptase (>200 ng/mL). Coagulation was normal.
Concepción Prats-Martín, Rosario M. Morales-Camacho   +1 more
openaire   +3 more sources

Circulating Cells with Macrophage-like Characteristics in Cancer: The Importance of Circulating Neoplastic-Immune Hybrid Cells in Cancer

Cancers, 2022
Cancer remains a significant cause of mortality in developed countries, due in part to difficulties in early detection, understanding disease biology, and assessing treatment response. If effectively harnessed, circulating biomarkers promise to fulfill these needs through non-invasive “liquid” biopsy.
Thomas L. Sutton, Ranish K. Patel, Ashley N. Anderson, Stephen G. Bowden, Riley Whalen, Nicole R. Giske, Melissa H. Wong   +6 more
openaire   +2 more sources

Label-free enrichment of rare unconventional circulating neoplastic cells using a microfluidic dielectrophoretic sorting device [PDF]

Communications Biology, 2021
AbstractCellular circulating biomarkers from the primary tumor such as circulating tumor cells (CTCs) and circulating hybrid cells (CHCs) have been described to harbor tumor-like phenotype and genotype. CHCs are present in higher numbers than CTCs supporting their translational potential. Methods for isolation of CHCs do not exist and are restricted to
Jose Montoya Mira, Ajay A. Sapre, Brett S. Walker, Jesus Bueno Alvarez, Kyle T. Gustafson, Eugene Tu, Jared M. Fischer, Melissa H. Wong, Sadik Esener, Yu-Jui Chiu   +9 more
openaire   +5 more sources

Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma [PDF]

Blood, 2019
Iyer and colleagues used deep sequencing of T-cell receptor genes to demonstrate clonal heterogeneity of mycosis fungoides, with repeated seeding of disparate clones from the blood.
Aishwarya Iyer, Weiwei Wang, Dylan Hennessey, Jordan Patterson, Gane Ka-Shu Wong, Robert Gniadecki, Robert Gniadecki, Sandra O'Keefe   +7 more
openaire   +6 more sources

Circulating Neoplastic-Immune Hybrid Cells Predict Metastatic Progression in Uveal Melanoma

Cancers, 2022
Background: Uveal melanoma is an aggressive cancer with high metastatic risk. Recently, we identified a circulating cancer cell population that co-expresses neoplastic and leukocyte antigens, termed circulating hybrid cells (CHCs). In other cancers, CHCs are more numerous and better predict oncologic outcomes compared to circulating tumor cells (CTCs).
Michael S. Parappilly, Yuki Chin, Riley M. Whalen, Ashley N. Anderson, Trinity S. Robinson, Luke Strgar, Thomas L. Sutton, Patrick Conley, Christopher Klocke, Summer L. Gibbs, Young Hwan Chang, Guanming Wu, Melissa H. Wong, Alison H. Skalet   +13 more
openaire   +2 more sources

Detection of arenavirus in a peripheral odontogenic fibromyxoma in a red tail boa (Boa constrictor constrictor) with inclusion body disease [PDF]

, 2015
A captive bred red tail boa (Boa constrictor constrictor) was presented with a large intraoral mass originating from the buccal gingiva, attached to the right dentary teeth row.
Ducatelle, Richard, Hellebuyck, Tom, Martel, An, Pasmans, Frank, Saey, Veronique   +4 more
core   +1 more source

Circulating Cell-Free DNA in Dogs with Mammary Tumors: Short and Long Fragments and Integrity Index [PDF]

, 2017
Circulating cell-free DNA (cfDNA) has been considered an interesting diagnostic/prognostic plasma biomarker in tumor-bearing subjects. In cancer patients, cfDNA can hypothetically derive from tumor necrosis/apoptosis, lysed circulating cells, and some ...
A Asmarinah, A Fawzy, A Jemal, A Matos, Alessandro Sammarco, Andrea Saccani, Antonio Mollo, BG Wang, BT Kurien, C Alix-Panabières, C Qian, CH Lee, Chiara Bedin, Chiara Romualdi, D Bostock, D El-Gayar, D Madhavan, D Merlo, Davide Trez, DMW Schaefer, Donato Nitti, E Coustan-Smith, E Gormally, EM Tan, F Salvianti, FH Igney, GB Gelaleti, Giorgia Beffagna, H Schwarzenbach, H Schwarzenbach, J Beck, J Ferlay, JC Thompson, K Jung, K Pilichou, K Sorenmo, K Sorenmo, Kristy L. Richards, KS Borge, L Ouyang, L Pena, L Pena, Laura Cavicchioli, LE Lowes, M Agostini, M Geng, M Goldschmidt, M Shackleton, M Stroun, M Stroun, Marco Agostini, Marta Mainenti, MB Giacona, Michelangelo Campanella, MV Jain, N Sleeckx, N Umetani, N Umetani, P Anker, P Hofman, P Rivera, R Agassi, R Brodey, R Kumaraguruparan, R Kumaraguruparan, Raffaella De Maria, Re Ellsworth, S Baspinar, S Cargnin, S Iqbal, S Jahr, S Volik, SA Leon, Silvia Ferro, T Hao, T Imamura, T Skvortsova, Valentina Zappulli, W Ayala, W Wang   +79 more
core   +5 more sources

Disseminated neoplasia in blue mussels, Mytilus galloprovincialis, from the Black Sea, Romania [PDF]

, 2005
Disseminated neoplasia, also called leukemia or hemic neoplasia, has been detected in 15 species of marine bivalve mollusks worldwide. The disease is characterized by the presence of single anaplastic cells with enlarged nuclei and sometimes frequent ...
Bower, Brousseau, Campalans, Corina Ciocan, Cosson-Mannevy, Elston, Elston, Elston, Elston, Farley, Farley, Farley, Farley, Figueras, Figueras, Fuentes, Gosling, Green, House, Inke Sunila, Kent, Kent, Lowe, Medina, Mix, Moore, Oprandy, Oprandy, Peters, Peters, Rasmussen, Reinisch, Sunila, Tiscar, Twomey, Usheva, Villalba, Zizzo   +37 more
core   +1 more source

Pivotal Role of Pervasive Neoplastic and Stromal Cells Reprogramming in Circulating Tumor Cells Dissemination and Metastatic Colonization [PDF]

Cancer Microenvironment, 2014
Reciprocal interactions between neoplastic cells and their microenvironment are crucial events in carcinogenesis and tumor progression. Pervasive stromal reprogramming and remodeling that transform a normal to a tumorigenic microenvironment modify numerous stromal cells functions, status redox, oxidative stress, pH, ECM stiffness and energy metabolism.
Kinan Drak Alsibai, André Nicolas, Didier Meseure   +2 more
openaire   +3 more sources