Results 1 to 10 of about 330,598 (225)

Heterogeneity of Circulating Tumor Cell Neoplastic Subpopulations Outlined by Single-Cell Transcriptomics [PDF]

Cancers, 2021
Fatal metastasis occurs when circulating tumor cells (CTCs) disperse through the blood to initiate a new tumor at specific sites distant from the primary tumor. CTCs have been classically defined as nucleated cells positive for epithelial cell adhesion molecule and select cytokeratins (EpCAM/CK/DAPI), while negative for the common lymphocyte marker ...
Christine M. Pauken, Shelby Ray Kenney, Kathryn J. Brayer, Yan Guo, Ursa A. Brown-Glaberman, Dario Marchetti   +5 more
semanticscholar   +4 more sources

Label-free enrichment of rare unconventional circulating neoplastic cells using a microfluidic dielectrophoretic sorting device [PDF]

Communications Biology, 2021
AbstractCellular circulating biomarkers from the primary tumor such as circulating tumor cells (CTCs) and circulating hybrid cells (CHCs) have been described to harbor tumor-like phenotype and genotype. CHCs are present in higher numbers than CTCs supporting their translational potential. Methods for isolation of CHCs do not exist and are restricted to
Jose Montoya Mira, Ajay A. Sapre, Brett S. Walker, Jesus Bueno Alvarez, Kyle T. Gustafson, Eugene Tu, Jared M. Fischer, Melissa H. Wong, Sadik Esener, Yu-Jui Chiu   +9 more
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Flow cytometry in the detection of circulating tumor cells in neoplastic effusions

Clinica Chimica Acta, 2023
Despite its limitations, the cytology of body fluids is widely used in diagnosing neoplastic cells. Flow cytometry detects and identifies individual cells, enabling the detection of circulating tumor cells and facilitating diagnosis. This study compared the diagnostic utility of flow cytometry and cytology for detecting cancer cells in peritoneal and ...
Karol Gostomczyk, Ewelina Łukaszewska, Jędrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Łukasz Szylberg   +6 more
openaire   +3 more sources

Circulating Cells with Macrophage-like Characteristics in Cancer: The Importance of Circulating Neoplastic-Immune Hybrid Cells in Cancer

Cancers, 2022
Cancer remains a significant cause of mortality in developed countries, due in part to difficulties in early detection, understanding disease biology, and assessing treatment response. If effectively harnessed, circulating biomarkers promise to fulfill these needs through non-invasive “liquid” biopsy.
Thomas L. Sutton, Ranish K. Patel, Ashley N. Anderson, Stephen G. Bowden, Riley Whalen, Nicole R. Giske, Melissa H. Wong   +6 more
openaire   +3 more sources

Circulating Neoplastic-Immune Hybrid Cells Predict Metastatic Progression in Uveal Melanoma

Cancers, 2022
Background: Uveal melanoma is an aggressive cancer with high metastatic risk. Recently, we identified a circulating cancer cell population that co-expresses neoplastic and leukocyte antigens, termed circulating hybrid cells (CHCs). In other cancers, CHCs are more numerous and better predict oncologic outcomes compared to circulating tumor cells (CTCs).
Michael S. Parappilly, Yuki Chin, Riley M. Whalen, Ashley N. Anderson, Trinity S. Robinson, Luke Strgar, Thomas L. Sutton, Patrick Conley, Christopher Klocke, Summer L. Gibbs, Young Hwan Chang, Guanming Wu, Melissa H. Wong, Alison H. Skalet   +13 more
openaire   +3 more sources

Pivotal Role of Pervasive Neoplastic and Stromal Cells Reprogramming in Circulating Tumor Cells Dissemination and Metastatic Colonization [PDF]

Cancer Microenvironment, 2014
Reciprocal interactions between neoplastic cells and their microenvironment are crucial events in carcinogenesis and tumor progression. Pervasive stromal reprogramming and remodeling that transform a normal to a tumorigenic microenvironment modify numerous stromal cells functions, status redox, oxidative stress, pH, ECM stiffness and energy metabolism.
Kinan Drak Alsibai, André Nicolas, Didier Meseure   +2 more
openaire   +4 more sources

Circulating angiogenic cells in glioblastoma: toward defining crucial functional differences in CAC-induced neoplastic versus reactive neovascularization

Neuro-Oncology Advances, 2020
AbstractBackgroundIn order to identify suitable therapeutic targets for glioma anti-angiogenic therapy, the process of neovascularization mediated by circulating angiogenic cells (CACs) needs to be scrutinized.MethodsIn the present study, we compared the expression of neovascularization-related genes by 3 circulating CAC subsets (hematopoietic ...
Peter J. van der Spek, Andrea Sacchetti, Dana A M Mustafa, Johan M. Kros, W A Dik, Karin Huizer, Sigrid M. A. Swagemakers   +6 more
openaire   +5 more sources

Prognostic Value of Multiple Reverse Transcription-PCR Tyrosinase Testing for Circulating Neoplastic Cells in Malignant Melanoma [PDF]

Clinical Chemistry, 2003
Abstract Background: The reverse transcription-PCR tyrosinase assay (TYR test) cannot reliably detect malignant melanoma (MM) cells in blood as the cells often circulate at low concentrations. We evaluated the prognostic value of multiple TYR testing, the prognostic significance of individual positive TYR test results (TYR+) in ...
Piotr Rutkowski, Agnieszka Synowiec, Janusz A. Siedlecki, Witold Kupść, Wiesław Wiktor-Jȩdrzejczak, Zbigniew Nowecki, Małgorzata Chomicka, Jerzy Strużyna, Jolanta Szenajch, Jadwiga Kulik, Bogdan Jasiński, Wlodzimierz Ruka   +11 more
openaire   +4 more sources

Magnetic Levitation and Sorting of Neoplastic Circulating Cell Hybrids

bioRxiv, 2022
AbstractCirculating hybrid cells (CHCs) are a novel, rare cell population that harbor tumor and immune cell phenotypes and genotypes and are detectible in peripheral blood. Several recent reports implicated CHCs in the metastatic cascade and found their enumeration to provide better prognostic value than conventionally-defined circulating tumor cells ...
Kaitlyn Liang, Sena Yaman, Ranish K. Patel, Michael S. Parappilly, Brett S. Walker, Melissa H. Wong, Naside Gozde Durmus   +6 more
openaire   +2 more sources

Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion

Blood, 2006
Abstract In multiple myeloma (MM), circulating endothelial cells (CECs) represent a vascular marker of angiogenesis and may reflect tumor mass. In this report, we showed that, in 5 MM patients with 13q14 deletion, CECs carried the same chromosome aberration as the neoplastic plasma cells (11%-32% of CECs with 13q14 deletion). Most of the
RIGOLIN, Gian Matteo, FRAULINI, Chiara, CICCONE, Maria, MAURO, Endri, BUGLI, Anna Maria, DE ANGELI, Cristiano, NEGRINI, Massimo, CUNEO, Antonio, CASTOLDI, Gianluigi   +8 more
openaire   +6 more sources