Label-free enrichment of rare unconventional circulating neoplastic cells using a microfluidic dielectrophoretic sorting device [PDF]
Communications Biology, 2021 Montoya Mira & Sapre et al. design a microfluidic device utilizing dielectrophoresis for the enrichment of circulating neoplastic cells that possess both epithelial and immune-like characteristics. They optimized the device using in vitro models and then
Jose Montoya Mira +9 more
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Detection of circulating hybrid cells and circulating tumor cells in cerebrospinal fluid for leptomeningeal metastasis diagnosis and therapeutic prediction [PDF]
Frontiers in Cell and Developmental BiologyPurposeLeptomeningeal metastasis (LM) represents a serious complication of advanced malignancies with poor prognosis. Conventional diagnostic approaches, such as MRI and cerebrospinal fluid (CSF) cytology lack sufficient sensitivity—particularly in early-
Yanting Liu +16 more
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Heterogeneity of Circulating Tumor Cell Neoplastic Subpopulations Outlined by Single-Cell Transcriptomics [PDF]
Cancers, 2021 Fatal metastasis occurs when circulating tumor cells (CTCs) disperse through the blood to initiate a new tumor at specific sites distant from the primary tumor. CTCs have been classically defined as nucleated cells positive for epithelial cell adhesion molecule and select cytokeratins (EpCAM/CK/DAPI), while negative for the common lymphocyte marker ...
Christine M. Pauken +5 more
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Current Status and Prospects of Liquid Biopsy for Hepatocellular Carcinoma
The Korean Journal of Gastroenterology, 2023 Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally. Early detection and treatment response monitoring of HCC are vital for improved outcomes.
Jumi Kang, Soon Sun Kim
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In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells [PDF]
Vojnosanitetski Pregled, 2016 Background/Aim. Numerous epidemiological studies have shown beneficial effects of cruciferous vegetables consumption in cancer chemoprevention.
Konić-Ristić Aleksandra +6 more
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Circulating hypergranular neoplastic cells: not always leukemic promyelocytes [PDF]
Blood, 2017 ![Figure][1] A 39-year-old woman presented with severe low back pain, hepatosplenomegaly, leukocytosis (15.9 × 109/L), anemia (7.3 g/dL), thrombocytopenia (48 × 109/L), and elevated serum tryptase (>200 ng/mL). Coagulation was normal.
Concepción Prats-Martín +1 more
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Circulating Cell-Free DNA in Dogs with Mammary Tumors: Short and Long Fragments and Integrity Index. [PDF]
PLoS ONE, 2017 Circulating cell-free DNA (cfDNA) has been considered an interesting diagnostic/prognostic plasma biomarker in tumor-bearing subjects. In cancer patients, cfDNA can hypothetically derive from tumor necrosis/apoptosis, lysed circulating cells, and some ...
Giorgia Beffagna +14 more
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Frontiers in Veterinary Science, 2021 Epithelial cell adhesion molecule (EpCAM) is a transmembrane protein expressed at intercellular junctions in epithelial cells. As an epithelial biomarker, it used for immunologic-based capture of epithelial-derived circulating tumor cells (CTCs) in human
Christa Y. Heyward +4 more
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Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors
Scientific Reports, 2021 Metastatic progression defines the final stages of tumor evolution and underlies the majority of cancer-related deaths. The heterogeneity in disseminated tumor cell populations capable of seeding and growing in distant organ sites contributes to the ...
Matthew S. Dietz +33 more
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European Radiology Experimental, 2023 Background We tested the hypothesis that radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) promotes tumor cell release and explored a method for reducing these effects.
Bowen Zhuang +8 more
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